Sulfinpirazon

Sulfinpirazon
Klinički podaci

Prodajno ime	Anturan, Anturane, Anturanil, Anturano
Drugs.com	Monografija
Način primene	Oralno
Farmakokinetički podaci
Poluvreme eliminacije	4-6 h

Identifikatori
CAS broj	57-96-5^Y
ATC kod	M04AB02 (WHO)
PubChem	CID 5342
DrugBank	DB01138^Y
ChemSpider	5149^Y
KEGG	C07317^Y
ChEBI	CHEBI:9342^Y
ChEMBL	CHEMBL832^Y
Hemijski podaci
Formula	C₂₃H₂₀N₂O₃S
Molarna masa	404,482
SMILES O=C1C(CCS(=O)C2=CC=CC=C2)C(=O)N(N1C1=CC=CC=C1)C1=CC=CC=C1
InChI InChI=1S/C23H20N2O3S/c26-22-21(16-17-29(28)20-14-8-3-9-15-20)23(27)25(19-12-6-2-7-13-19)24(22)18-10-4-1-5-11-18/h1-15,21H,16-17H2^Y Key:MBGGBVCUIVRRBF-UHFFFAOYSA-N^Y

Fizički podaci
Tačka topljenja	136—137 °C (277—279 °F)

Sulfinpirazon je organsko jedinjenje, koje sadrži 23 atoma ugljenika i ima molekulsku masu od 404,482 Da.^[1]^[2]

Osobine

Osobina	Vrednost
Broj akceptora vodonika	3
Broj donora vodonika	0
Broj rotacionih veza	6
Particioni koeficijent^[3] (ALogP)	3,4
Rastvorljivost^[4] (logS, log(mol/L))	-5,3
Polarna površina^[5] (PSA, Å²)	76,9

Reference

^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.
^ David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.
^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o.
^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

Literatura

Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.

Spoljašnje veze

Sulfinpyrazone

Molimo Vas, obratite pažnju na važno upozorenje
u vezi sa temama iz oblasti medicine (zdravlja).

Read other articles:

Alaban tanah

Alaban tanah Klasifikasi ilmiah Domain: Eukaryota Kerajaan: Plantae Divisi: Magnoliophyta Kelas: Magnoliopsida Subkelas: Asteridae Ordo: Lamiales Famili: Lamiaceae Subfamili: Viticoideae Genus: Vitex Spesies: Vitex rotundifoliaL.f. Sinonim[1] Vitex ovata Thunb. Vitex repens Blanco Vitex rotundifolia f. albiflora Y.N.Lee Vitex rotundifolia f. albiflora S.S.Ying Vitex rotundifolia f. rosea Satomi Vitex trifolia subsp. litoralis Steenis Vitex trifolia var. obovata Benth. Vitex trifolia ...

Battles of the Isonzo

Series of major battles between Italy and Austria-Hungary during WWIFor the Ostrogoth invasion of Italy, see Battle of Isonzo (489). This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.Find sources: Battles of the Isonzo – news · newspapers · books · scholar · JSTOR (January 2014) (Learn how and when to remove this template m...

Baliato di Jersey

Jersey (dettagli) (dettagli) Jersey - Localizzazione Dati amministrativi Nome completo Baliato di Jersey Nome ufficiale Bailiwick of Jersey Dipendente da Corona Britannica[1] Lingue ufficiali inglese Altre lingue jèrriais, francese Capitale Saint Helier (28 100 ab.) Politica Status Dipendenza della Corona britannica Duca di Normandia Carlo III Ministro capo Ian Gorst Superficie Totale 116 km² Popolazione Totale 107 800 ab. (2019) Densità 912 ab./km² Geografia...

Helikase

Helikase yang umum ditemukan adalah Helikase DNA dan Helikase RNA. Helikase DNA memiliki nomor EC 3.6.4.12 dan berperan dalam proses replikasi DNA.[1][2] Berbeda dengan helikase DNA, helikase RNA memiliki nomor EC 3.6.4.13 dan berperan dalam proses translasi.[2][3] Arti dari nomor EC 3 adalah enzim ini termasuk kelas enzim hidrolisis.[2] Mekanisme kerja helikase DNA adalah membentuk komplek nucleoprotein, disebut replisome, dengan primase dan memotong i...

Diocesi di Mondovì

Diocesi di MondovìDioecesis Montis Regalis in Pedemonte o Montis ViciChiesa latinaSuffraganea dell'arcidiocesi di Torino Regione ecclesiasticaPiemonte Provincia ecclesiastica Collocazione geografica VescovoEgidio Miragoli Vicario generaleFlavio Begliatti Vescovi emeritiLuciano Pacomio Presbiteri91, di cui 81 secolari e 10 regolari1.237 battezzati per presbitero Religiosi18 uomini, 121 donne Diaconi22 permanenti Abitanti123.510 Battezzati112.640 (91,2% del totale) StatoItal...

Superliga 2016-2017 (Slovacchia)

Superliga 2016-2017Fortuna Liga 2016-2017 Competizione Superliga Sport Calcio Edizione 24ª Organizzatore SFZ Date dal 16 luglio 2016al 27 maggio 2017 Luogo Slovacchia Partecipanti 12 Risultati Vincitore Žilina(7º titolo) Retrocessioni Spartak Myjava Statistiche Miglior marcatore Filip Hlohovský Seydouba Soumah (20 gol) Incontri disputati 165 Gol segnati 455 (2,76 per incontro) Cronologia della competizione 2015-2016 2017-2018 Manuale La Superliga 2016-...

Muhammad al-Idrisi

Muhammad Al-IdrisiTabula Rogeriana digambar oleh Al-Idrisi untuk Roger II dari Sisilia pada tahun 1154, menjadikannya sebagai salah satu dari peta-peta dunia kuno. Penggabungan modern dibuat dari 70 lembar halaman ganda dari atlas aslinya.Lahir1100CeutaMeninggal1160SisiliaKebangsaanMurabitunDikenal atasTabula RogerianaKarier ilmiahBidangPakar Geografi dan Kartografi, Penulis, dan IlmuwanTerinspirasiIbnu Batuta, Ibnu Khaldun, Piri Reis dan Barbary Corsairs Syarif Abu Abdullah Muhammad Al-Idri...

Voya Financial

American financial services company Voya Financial, Inc.Headquarters at Helmsley BuildingCompany typePublic companyTraded asNYSE: VOYAS&P 400 componentIndustryFinancial servicesPredecessorING U.S.Founded1991; 33 years ago (1991)(As an ING subsidiary)HeadquartersHelmsley BuildingNew York City, U.S.Key peopleRodney O. Martin, Jr.(Chairman & CEO)Michael S. Smith(CFO)ProductsRetirement servicesInsuranceAsset managementEmployee benefitsRevenue US$7.6 billion (2020)Op...

Taiwan consensus

Taiwanese political term You can help expand this article with text translated from the corresponding article in Chinese. (December 2013) Click [show] for important translation instructions. Machine translation, like DeepL or Google Translate, is a useful starting point for translations, but translators must revise errors as necessary and confirm that the translation is accurate, rather than simply copy-pasting machine-translated text into the English Wikipedia. Do not translate text tha...

Sergei Vasilyev (director)

Soviet film director This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.Find sources: Sergei Vasilyev director – news · newspapers · books · scholar · JSTOR (June 2019) (Learn how and when to remove this message) Sergei VasilyevBorn(1900-11-04)4 November 1900Moscow, Russian EmpireDied16 December 1959(1959-12-16) (aged&#...

Contekan

Beberapa atau seluruh referensi dari artikel ini mungkin tidak dapat dipercaya kebenarannya. Bantulah dengan memberikan referensi yang lebih baik atau dengan memeriksa apakah referensi telah memenuhi syarat sebagai referensi tepercaya. Referensi yang tidak benar dapat dihapus sewaktu-waktu. Contekan Kata contek adalah bentuk tidak baku dari kata sontek sehingga penulisan yang benar adalah sontek. Penulisan kata yang benar disebut juga dengan kata baku yaitu kata yang penulisannya sesuai denga...

فيليب السادس ملك إسبانيا

فيليب السادس ملك إسبانيا (بالإسبانية: Felipe VI)‏ خوان كارلوس الأول خوان كارلوس الأول (أمير إسبانيا) معلومات شخصية اسم الولادة (بالإسبانية: Felipe Juan Pablo Alfonso de Todos los Santos de Borbón y Grecia)‏ الميلاد 30 يناير 1968 (56 سنة)[1][2] إسبانيا (مدريد) المعمودية 8 فبراير 1968 �...

Hardin County Line

1990 studio album by Mark CollieHardin County LineStudio album by Mark CollieReleasedMarch 29, 1990Recorded1989StudioGroundStar Lab, Sound Emporium Studios, and Sound Stage Studios, Nashville, TNGenreCountryLength29:46LabelMCA RecordsProducerTony BrownDoug JohnsonMark Collie chronology Hardin County Line(1990) Born and Raised in Black & White(1991) Singles from Hardin County Line Something With a Ring to ItReleased: January 1990 Looks Aren't EverythingReleased: June 9, 1990 Hardin...

1962 Maine gubernatorial election

1962 Maine gubernatorial election ← 1960 (special) November 6, 1962 1966 → Nominee John H. Reed Maynard Dolloff Party Republican Democratic Popular vote 146,604 146,121 Percentage 50.1% 49.9% County resultsReed: 50–60% 60–70%Dolloff: 50–60% 60–70% Governor before election John H. Reed Republican Elected Governor John H. Reed Republi...

Richmond Opera

Richmond OperaChoirRichmond Opera logoOriginIsleworth, England, United KingdomFounded2004 (2004)GenreOperaMusic directorHelena Brown (2002–2012)Leslie A. Lewis (2012–2013)Janet Oates (2014)Lindsay Bramley (from 2015)Websiterichmondopera.org.uk Richmond Opera is an opera company based in Richmond, London in the UK. Originally founded as Isleworth Baroque in 2004, Richmond Opera performs a fully-staged opera each year at the Normansfield Theatre in Teddington, along with concerts, sem...

Zero interest-rate policy

Macroeconomic concept describing conditions with a very low nominal interest rate This article needs to be updated. Please help update this article to reflect recent events or newly available information. (September 2021) Japan bonds Inverted yield curve in 1990 Zero interest-rate policy starting in 1995 Negative interest rate policy started in 2014 30 year 20 year 10 year 5 year 2 year 1 year Japan money supply and infla...

Cedrus

Genus of plants (coniferous trees) Cedar (genus) redirects here. For other trees with the name, see List of plants known as cedar. CedarTemporal range: Albian–Recent PreꞒ Ꞓ O S D C P T J K Pg N Lebanon cedar in Al Shouf Cedar Nature Reserve in Barouk, Lebanon Scientific classification Kingdom: Plantae Clade: Tracheophytes Clade: Gymnospermae Division: Pinophyta Class: Pinopsida Order: Pinales Family: Pinaceae Subfamily: Abietoideae Genus: CedrusTrew Type species Cedrus elegansKnight. Sp...

أبيا

أبيا منظر للمباني الحكومية في أبيا أسماء أخرى Apia الاسم الرسمي أبيا خريطة أبيا الإحداثيات 13°50′00″S 171°50′00″W / 13.833333333333°S 171.83333333333°W / -13.833333333333; -171.83333333333 تأسست 1850 اصبحت عاصمة 1959 تقسيم إداري الدولة ساموا عاصمة لـ سامواأوبولو خصائص جغرافية المساحة 123.8...

محمد عبد الله حسن محمد

محمد عبد الله حسن محمد معلومات شخصية الميلاد 2 ديسمبر 1978 (46 سنة) دبي مواطنة الإمارات العربية المتحدة الحياة العملية المهنة حكم كرة قدم الرياضة كرة القدم[1] بلد الرياضة الإمارات العربية المتحدة تعديل مصدري - تعديل محمد عبد الله حسن محمد (مواليد ...

Paraná Clube

ParanáParaná Clube logoNama lengkapParaná ClubeJulukanTricolor da Vila CapanemaBerdiriDecember 19, 1989StadionEstádio Vila Capanema and Estádio Vila Olímpica, Curitiba, Brazil(Kapasitas: 20,000 (Durival de Brito), and 18,500 (Vila Olímpica))PresidentLeonardo OliveiraHead CoachRogério MicaleLigaCampeonato Brasileiro2018Campeonato Brasileiro to dispute Kostum kandang Kostum tandang Paraná Clube adalah nama tim sepak bola Brasil yang bermarkas di Curitiba, Brasil. Tim ini berdiri tahun ...