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Sfingomijelinska fosfodiestaraza D
Sfingomijelinska fosfodiestaraza D
Identifikatori
EC broj	3.1.4.41
CAS broj	54992-31-3
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
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Sfingomijelinska fosfodiestaraza D (EC 3.1.4.41, sfingomijelinaza D) je enzim sa sistematskim imenom sphingomijelin keramid-fosfohidrolaza.^[1]^[2] Ovaj enzim katalizuje sledeću hemijsku reakciju

sfingomijelin + H₂O

\rightleftharpoons

keramid fosfat + holin

Ovaj enzim ne deluje na fosfatidilholin, ali hidrolizuje 2-lizofosfatidilholin do holina i 2-lizofosfatidata.

Reference

^ Carne, H.R. & Onon, E. (1978). „Action of Corynebacterium ovis exotoxin on endothelial cells of blood vessels”. Nature. 271: 246—248. PMID 622164.
^ Soucek, A., Michalec, C. and Souckov, A. (1971). „Identification and characterization of a new enzyme of the group phospholipase D isolated from Corynebacterium ovis”. Biochim. Biophys. Acta. 227: 116—128. PMID 5543581.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.

Spoljašnje veze

Sphingomyelin+phosphodiesterase+D на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Carne, H.R. & Onon, E. (1978). „Action of Corynebacterium ovis exotoxin on endothelial cells of blood vessels”. Nature. 271: 246—248. PMID 622164.

[2] Soucek, A., Michalec, C. and Souckov, A. (1971). „Identification and characterization of a new enzyme of the group phospholipase D isolated from Corynebacterium ovis”. Biochim. Biophys. Acta. 227: 116—128. PMID 5543581.

[1]

[2]