Receptor retinoinske kiseline beta

Receptor retinoinske kiseline, beta
PDB slika je bazirana na 1xap.
Dostupne strukture
1dsz​, 1hra​, 1xap​, 1xdk​
Identifikatori
Simboli RARB; HAP; NR1B2; RRB2
Vanjski ID OMIM: 180220 MGI: 97857 HomoloGene: 68100 GeneCards: RARB Gene
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 5915 218772
Ensembl ENSG00000077092 ENSMUSG00000017491
UniProt P10826 Q8K1P6
RefSeq (mRNA) NM_000965 NM_011243
RefSeq (protein) NP_000956 NP_035373
Lokacija (UCSC) Chr 3:
25.19 - 25.61 Mb		 Chr 14:
15.22 - 15.61 Mb
PubMed pretraga [1] [2]

Receptor retinoinske kiseline beta (RAR-beta), also known as NR1B2 (nuclear receptor subfamily 1, group B, member 2) is a nuclear receptor encoded by the RARB gene.[1]

Ovaj gen kodira receptor retinoinske kiseline beta, koji je član tiroid-steroid hormon receptorske super-familije nuklearnih transkripcionih regulatora. Ovaj receptor je lokalizovan u citoplazmi i u sub-nuklearnim kompartmanima. On vezuje retinoinsku kiselinu, biološki aktivnu formu vitamina A čime posreduje ćelijsku signalizaciju embrionske morfogene, ćelijski rast i diferencijaciju. Smatra se da ovaj protein ograničava rast mnogih ćelijskih tipova putem regulacije izražavanja gena. Ovaj gen je prvo identifikovan kod hepatocelularnih karcinoma, kod kojih se on nalazi pored integracionog mesta hepatitis B virusa. Ovaj gen izražava najmanje dve transkriptne varijante; jedan dodatni transkript je bio opisan, ali puna dužina njegovog proteina nije bila određena.[1]

Interakcije

Pokazano je da receptor retinoinske kiseline beta ima interakciju sa Nuklearni receptor srodnim 1 proteinom.[2]

Reference

  1. ^ а б „Entrez Gene: RARB retinoic acid receptor, beta”. 
  2. ^ Perlmann, T; Jansson, L. (1995). „A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1”. Genes Dev. UNITED STATES. 9 (7): 769—82. ISSN 0890-9369. PMID 7705655. 

Literatura

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  • de Thé H, Marchio A, Tiollais P, Dejean A (1988). „A novel steroid thyroid hormone receptor-related gene inappropriately expressed in human hepatocellular carcinoma.”. Nature. 330 (6149): 667—70. PMID 2825037. doi:10.1038/330667a0. 
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