Receptor insulinu sličnog faktora rasta 2

Receptor insulinu sličnog faktora rasta 2‎
PDB prikaz baziran na 1e6f​.
Dostupne strukture
1E6F​, 1GP0​, 1GP3​, 1GQB​, 1JWG​, 1LF8​, 2CNJ​, 2L29​, 2L2A​, 2V5N​, 2V5O​, 2V5P​
Identifikatori
Simboli IGF2R; CD222; CIMPR; M6P-R; MPR1; MPRI
Vanjski ID OMIM: 147280 MGI: 96435 HomoloGene: 676 GeneCards: IGF2R Gene
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 3482 16004
Ensembl ENSG00000197081 ENSMUSG00000023830
UniProt P11717 Q07113
RefSeq (mRNA) NM_000876.2 NM_010515.2
RefSeq (protein) NP_000867.2 NP_034645.2
Lokacija (UCSC) Chr 6:
160.39 - 160.53 Mb		 Chr 17:
12.68 - 12.77 Mb
PubMed pretraga [1] [2]

Receptor insulinu sličnog faktora rasta 2 (IGF2R, katjionski nezavisni receptor manoza-6-fosfata, CI-MPR) je protein koji je kod ljudi kodiran IGF2R genom.[1][2] IGF2R je multifunkcionalni proteinski receptor za koji se vezuje insulinu sličan faktor rasta 2 (IGF2) na ćelijskoj površini i manoza-6-fosfat (M6P)-obeležene proteine u trans-Goldžijevom apararu.[2]

Interakcije

Receptor insulinu sličnog faktora rasta 2 formira interakcije sa M6PRBP1.[3][4]

Reference

  1. ^ Oshima A, Nolan CM, Kyle JW, Grubb JH, Sly WS (1988). „The human cation-independent mannose 6-phosphate receptor. Cloning and sequence of the full-length cDNA and expression of functional receptor in COS cells”. J. Biol. Chem. 263 (5): 2553—62. PMID 2963003. 
  2. ^ а б Laureys G, Barton DE, Ullrich A, Francke U (1988). „Chromosomal mapping of the gene for the type II insulin-like growth factor receptor/cation-independent mannose 6-phosphate receptor in man and mouse”. Genomics. 3 (3): 224—9. PMID 2852162. doi:10.1016/0888-7543(88)90083-3. 
  3. ^ Díaz E, Pfeffer SR (1998). „TIP47: a cargo selection device for mannose 6-phosphate receptor trafficking”. Cell. 93 (3): 433—43. PMID 9590177. doi:10.1016/S0092-8674(00)81171-X. 
  4. ^ Orsel JG, Sincock PM, Krise JP, Pfeffer SR (2000). „Recognition of the 300-kDa mannose 6-phosphate receptor cytoplasmic domain by 47-kDa tail-interacting protein”. Proc. Natl. Acad. Sci. U.S.A. 97 (16): 9047—51. PMC 16819 Слободан приступ. PMID 10908666. doi:10.1073/pnas.160251397. 

Literatura

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  • Hawkes C, Kar S (2004). „The insulin-like growth factor-II/mannose-6-phosphate receptor: structure, distribution and function in the central nervous system”. Brain Res. Brain Res. Rev. 44 (2–3): 117—40. PMID 15003389. doi:10.1016/j.brainresrev.2003.11.002. 
  • Scott CD, Firth SM (2005). „The role of the M6P/IGF-II receptor in cancer: tumor suppression or garbage disposal?”. Horm. Metab. Res. 36 (5): 261—71. PMID 15156403. doi:10.1055/s-2004-814477. 
  • Antoniades HN, Galanopoulos T, Neville-Golden J, Maxwell M (1992). „Expression of insulin-like growth factors I and II and their receptor mRNAs in primary human astrocytomas and meningiomas; in vivo studies using in situ hybridization and immunocytochemistry”. Int. J. Cancer. 50 (2): 215—22. PMID 1370435. doi:10.1002/ijc.2910500210. 
  • Zhou J, Bondy C (1992). „Insulin-like growth factor-II and its binding proteins in placental development”. Endocrinology. 131 (3): 1230—40. PMID 1380437. doi:10.1210/en.131.3.1230. 
  • Morgan DO; Edman JC; Standring DN; et al. (1987). „Insulin-like growth factor II receptor as a multifunctional binding protein”. Nature. 329 (6137): 301—7. PMID 2957598. doi:10.1038/329301a0. 
  • Oshima A; Nolan CM; Kyle JW; et al. (1988). „The human cation-independent mannose 6-phosphate receptor. Cloning and sequence of the full-length cDNA and expression of functional receptor in COS cells”. J. Biol. Chem. 263 (5): 2553—62. PMID 2963003. 
  • De Souza AT; Hankins GR; Washington MK; et al. (1996). „M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity”. Nat. Genet. 11 (4): 447—9. PMID 7493029. doi:10.1038/ng1295-447. 
  • Ilvesmäki V, Blum WF, Voutilainen R (1994). „Insulin-like growth factor binding proteins in the human adrenal gland”. Mol. Cell. Endocrinol. 97 (1–2): 71—9. PMID 7511544. doi:10.1016/0303-7207(93)90212-3. 
  • De Souza AT; Hankins GR; Washington MK; et al. (1995). „Frequent loss of heterozygosity on 6q at the mannose 6-phosphate/insulin-like growth factor II receptor locus in human hepatocellular tumors”. Oncogene. 10 (9): 1725—9. PMID 7753549. 
  • Schmidt B; Kiecke-Siemsen C; Waheed A; et al. (1995). „Localization of the insulin-like growth factor II binding site to amino acids 1508-1566 in repeat 11 of the mannose 6-phosphate/insulin-like growth factor II receptor”. J. Biol. Chem. 270 (25): 14975—82. PMID 7797478. doi:10.1074/jbc.270.25.14975. 
  • Rao PH; Murty VV; Gaidano G; et al. (1994). „Subregional mapping of 8 single copy loci to chromosome 6 by fluorescence in situ hybridization”. Cytogenet. Cell Genet. 66 (4): 272—3. PMID 8162705. doi:10.1159/000133710. 
  • Ishiwata T; Bergmann U; Kornmann M; et al. (1997). „Altered expression of insulin-like growth factor II receptor in human pancreatic cancer”. Pancreas. 15 (4): 367—73. PMID 9361090. doi:10.1097/00006676-199711000-00006. 
  • Tikkanen R; Peltola M; Oinonen C; et al. (1998). „Several cooperating binding sites mediate the interaction of a lysosomal enzyme with phosphotransferase”. EMBO J. 16 (22): 6684—93. PMC 1170273 Слободан приступ. PMID 9362483. doi:10.1093/emboj/16.22.6684. 
  • Nykjaer A; Christensen EI; Vorum H; et al. (1998). „Mannose 6-Phosphate/Insulin-like Growth Factor–II Receptor Targets the Urokinase Receptor to Lysosomes via a Novel Binding Interaction”. J. Cell Biol. 141 (3): 815—28. PMC 2132758 Слободан приступ. PMID 9566979. doi:10.1083/jcb.141.3.815. 
  • Díaz E, Pfeffer SR (1998). „TIP47: a cargo selection device for mannose 6-phosphate receptor trafficking”. Cell. 93 (3): 433—43. PMID 9590177. doi:10.1016/S0092-8674(00)81171-X. 
  • Wan L; Molloy SS; Thomas L; et al. (1998). „PACS-1 defines a novel gene family of cytosolic sorting proteins required for trans-Golgi network localization”. Cell. 94 (2): 205—16. PMID 9695949. doi:10.1016/S0092-8674(00)81420-8. 
  • Killian JK, Jirtle RL (1999). „Genomic structure of the human M6P/IGF2 receptor”. Mamm. Genome. 10 (1): 74—7. PMID 9892739. doi:10.1007/s003359900947. 
  • Kumar S; Hand AT; Connor JR; et al. (1999). „Identification and cloning of a connective tissue growth factor-like cDNA from human osteoblasts encoding a novel regulator of osteoblast functions”. J. Biol. Chem. 274 (24): 17123—31. PMID 10358067. doi:10.1074/jbc.274.24.17123. 

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