Protein A

Protein A
Struktura domena proteina A. On se kao troheliksni svežanj vezuje za teški promenljivi lanac VH3 ljudskog Fab-a[1] (levo). Minimizovani protein A vezan za Fc fragment Rituksimaba.[2]
Identifikatori
SimbolSpA
SCOP1DEE
SUPERFAMILY1DEE

Protein A je površinski MSCRAMM protein sa 56 kDa. On je originalno nađen u ćelijskom zidu bakterije Staphylococcus aureus. Protein A je kodiran SpA genom. Njegova regulacija je kontrolisana DNK topologijom, ćelijskom osmolarnošću, i tvokomponentnim sistem ArlS-ArlR. On je našao primenu u biohemijskim istraživanjima usled njegove sposobnosti vezivanja za imunoglobuline. On se sastoji od pet homolognih Ig vezujućih domena koji formiraju triheliksne svežnjeve. Svaki domen ima sposobnost vezivanja proteina mnogih vrsta sisara, a posebno IgG proteina. On se vezuje za teški lanac Fc regiona većine imunoglobulina, a isto tako i za Fab region u slučaju ljudske VH3 familije.

Reference

  1. ^ Graille M, Stura EA, Corper AL, Sutton BJ, Taussig MJ, Charbonnier JB, Silverman GJ (2000). „Crystal structure of a Staphylococcus aureus protein A domain complexed with the Fab fragment of a human IgM antibody: structural basis for recognition of B-cell receptors and superantigen activity.”. Proc Natl Acad Sci U S A. 97 (10): 5399—404. PMC 25840 Слободан приступ. PMID 10805799. 
  2. ^ Idusogie EE, Presta LG, Gazzano-Santoro H, Totpal K, Wong PY, Ultsch M, Meng YG, Mulkerrin MG (2000). „Mapping of the C1q binding site on rituxan, a chimeric antibody with a human IgG1 Fc.”. J Immunol. 164 (8): 4178—84. PMID 10754313. 

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