Peptidoglikan-N-acetilglukozaminska deacetilaza

Peptidoglikan-N-acetilglukozaminska deacetilaza
Identifikatori
EC broj3.5.1.104
Baze podataka
IntEnzIntEnz pregled
BRENDABRENDA pristup
ExPASyNiceZyme pregled
KEGGKEGG pristup
MetaCycmetabolički put
PRIAMprofil
Strukture PBPRCSB PDB PDBe PDBj PDBsum

Peptidoglikan-N-acetilglukozaminska deacetilaza (EC 3.5.1.104, HP310, PgdA, SpPgdA, BC1960, peptidoglikanska deacetilaza, peptidoglikan GlcNAc deacetilaza, peptidoglikan N-acetilglukozaminska deacetilaza, PG N-deacetilaza) je enzim sa sistematskim imenom peptidoglikan-N-acetilglukozamin amidohidrolaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju

peptidoglikan-N-acetil-D-glukozamin + H2O peptidoglikan-D-glukozamin + acetat

Modifikacija peptidoglikana N-deacetilacijom je važan faktor virulencije Helicobacter pylori, Listeria monocytogenes i Streptococcus suis vrsta.

Reference

  1. ^ Psylinakis, E., Boneca, I.G., Mavromatis, K., Deli, A., Hayhurst, E., Foster, S.J., Varum, K.M. and Bouriotis, V. (2005). „Peptidoglycan N-acetylglucosamine deacetylases from Bacillus cereus, highly conserved proteins in Bacillus anthracis”. J. Biol. Chem. 280: 30856—30863. PMID 15961396. 
  2. ^ Tsalafouta, A., Psylinakis, E., Kapetaniou, E.G., Kotsifaki, D., Deli, A., Roidis, A., Bouriotis, V. and Kokkinidis, M. (2008). „Purification, crystallization and preliminary X-ray analysis of the peptidoglycan N-acetylglucosamine deacetylase BC1960 from Bacillus cereus in the presence of its substrate (GlcNAc)6”. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 64: 203—205. PMID 18323609. 
  3. ^ Blair, D.E., Schuttelkopf, A.W., MacRae, J.I. and van Aalten, D.M. (2005). „Structure and metal-dependent mechanism of peptidoglycan deacetylase, a streptococcal virulence factor”. Proc. Natl. Acad. Sci. USA. 102: 15429—15434. PMID 16221761. 
  4. ^ Wang, G., Olczak, A., Forsberg, L.S. and Maier, R.J. (2009). „Oxidative stress-induced peptidoglycan deacetylase in Helicobacter pylori”. J. Biol. Chem. 284: 6790—6800. PMID 19147492. 
  5. ^ Popowska, M., Kusio, M., Szymanska, P. and Markiewicz, Z. (2009). „Inactivation of the wall-associated de-N-acetylase (PgdA) of Listeria monocytogenes results in greater susceptibility of the cells to induced autolysis”. J. Microbiol. Biotechnol. 19: 932—945. PMID 19809250. 
  6. ^ Fittipaldi, N., Sekizaki, T., Takamatsu, D., de la Cruz Domínguez-Punaro, M., Harel, J., Bui, N.K., Vollmer, W. and Gottschalk, M. (2008). „Significant contribution of the pgdA gene to the virulence of Streptococcus suis”. Mol. Microbiol. 70: 1120—1135. PMID 18990186. 

Literatura

Spoljašnje veze