Peptidilna dipeptidaza B

Peptidilna dipeptidaza B
Identifikatori
EC broj3.4.15.4
CAS broj147014-93-5
Baze podataka
IntEnzIntEnz pregled
BRENDABRENDA pristup
ExPASyNiceZyme pregled
KEGGKEGG pristup
MetaCycmetabolički put
PRIAMprofil
Strukture PBPRCSB PDB PDBe PDBj PDBsum

Peptidilna dipeptidaza B (EC 3.4.15.4, dipeptidilna karboksihidrolaza, atriopeptinska konvertaza, atrijalna di-(tri)peptidilna karboksihidrolaza, peptidilnadipeptidaza B, atrijalna dipeptidilna karboksihidrolaza, atrijalna peptidna konvertaza) je enzim.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju

Odvajanje C-terminalnog dipeptida ili u retkim slučajevima tripeptida

Ova membranska, cinkova metalopeptidaza je prisutan u sisarskim atrijalnim miocitima.

Reference

  1. ^ Harris, R.B. & Wilson, I.B. (1984). „Atrial tissue contains a metallo dipeptidyl carboxyhydrolase not present in ventricular tissue: partial purification and characterization”. Arch. Biochem. Biophys. 233: 667—675. PMID 6385859. 
  2. ^ Harris, R.B. & Wilson, I.B. (1985). „Conversion of atriopeptin II to atriopeptin I by atrial dipeptidyl carboxy hydrolase”. Peptides (Fayetteville). 6: 393—396. PMID 2999723. 
  3. ^ Soler, D.F. & Harris, R.B. (1988). „Continuous fluorogenic substrates for atrial dipeptidyl carboxyhydrolase. Importance of Ser in the P1 position”. Int. J. Peptide Protein Res. 32: 35—40. PMID 3146555. 
  4. ^ Soler, D.F. & Harris, R.B. (1989). „Atrial dipeptidyl carboxyhydrolase is a zinc-metallo proteinase which possesses tripeptidyl carboxyhydrolase activity”. Peptides (Fayetteville). 10: 63—68. PMID 2501770. 

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