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Metilisana-tiol-koenzim M metiltransferaza
Metilisana-tiol-koenzim M metiltransferaza
Identifikatori
EC broj	2.1.1.251
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
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Metilisana-tiol-koenzim M metiltransferaza (EC 2.1.1.251, mtsA (gen)) je enzim sa sistematskim imenom metilated-tiol:koenzim M metiltransferaza.^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

metantiol + koenzim M

\rightleftharpoons

metil-KoM + vodonik sulfid (sveukupna reakcija)

(1a) metantiol + [Co(I) metilisani-tiol-specifični korinoidni protein]

\rightleftharpoons

[metil-Co(III) metilisani-tiol-specifični korinoidni protein] + vodonik sulfid

(1b) [metil-Co(III) metilisani-tiol-specifični korinoidni protein] + koenzim M

\rightleftharpoons

metil-KoM + [Co(I) metilisani-tiol-specifični korinoidni protein]

Ovaj enzim učestvuje u metanogenezi metilisanih tiola, poput metan tiola, dimetil sulfida, i 3-S-metilmerkaptopropionata.

Reference

^ Paul, L. & Krzycki, J.A. (1996). „Sequence and transcript analysis of a novel Methanosarcina barkeri methyltransferase II homolog and its associated corrinoid protein homologous to methionine synthase”. J. Bacteriol. 178: 6599—6607. PMID 8932317.
^ Tallant, T.C. & Krzycki, J.A. (1997). „Methylthiol:coenzyme M methyltransferase from Methanosarcina barkeri, an enzyme of methanogenesis from dimethylsulfide and methylmercaptopropionate”. J. Bacteriol. 179: 6902—6911. PMID 9371433.
^ Tallant, T.C., Paul, L. and Krzycki, J.A. (2001). „The MtsA subunit of the methylthiol:coenzyme M methyltransferase of Methanosarcina barkeri catalyses both half-reactions of corrinoid-dependent dimethylsulfide: coenzyme M methyl transfer”. J. Biol. Chem. 276: 4485—4493. PMID 11073950.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.

Spoljašnje veze

Methylated-thiol---coenzyme+M+methyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Paul, L. & Krzycki, J.A. (1996). „Sequence and transcript analysis of a novel Methanosarcina barkeri methyltransferase II homolog and its associated corrinoid protein homologous to methionine synthase”. J. Bacteriol. 178: 6599—6607. PMID 8932317.

[2] Tallant, T.C. & Krzycki, J.A. (1997). „Methylthiol:coenzyme M methyltransferase from Methanosarcina barkeri, an enzyme of methanogenesis from dimethylsulfide and methylmercaptopropionate”. J. Bacteriol. 179: 6902—6911. PMID 9371433.

[3] Tallant, T.C., Paul, L. and Krzycki, J.A. (2001). „The MtsA subunit of the methylthiol:coenzyme M methyltransferase of Methanosarcina barkeri catalyses both half-reactions of corrinoid-dependent dimethylsulfide: coenzyme M methyl transfer”. J. Biol. Chem. 276: 4485—4493. PMID 11073950.

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