PROFILPELAJAR.COM

Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Memapsin 2
Memapsin 2
Identifikatori
EC broj	3.4.23.46
CAS broj	158736-49-3
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Memapsin 2 (EC 3.4.23.46, beta-sekretaza, enzim 1 razlaganja beta-mesta Alchajmerovog amiloidnog prekursornog proteina, BACE1) je enzim.^[1]^[2] Ovaj enzim katalizuje sledeću hemijsku reakciju

Široka endopeptidazna specifičnost. Razlaže se Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe u švedkoj varijanti Alchajmerovog amiloidnog prekursornog proteina

Ovaj enzim pripada peptidaznoj familiji A1.

Reference

^ Turner, R.T., III, K oelsch, G., Hong, L., Castenheira, P., Ghosh, A. and Tang, J. (2001). „Subsite specificity of memapsin 2 (β-secretase): implications for inhibitor design”. Biochemistry. 40: 10001—10006. PMID 11513577.
^ Hong, L., Turner, R.T., Koelsch, G., Shin, D., Ghosh, A.K. and Tang, J. (2002). „Crystal structure of memapsin 2 (β-secretase) in complex with an inhibitor OM00-3”. Biochemistry. 41: 10963—10967. PMID 12206667.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.

Spoljašnje veze

Memapsin+2 на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Turner, R.T., III, K oelsch, G., Hong, L., Castenheira, P., Ghosh, A. and Tang, J. (2001). „Subsite specificity of memapsin 2 (β-secretase): implications for inhibitor design”. Biochemistry. 40: 10001—10006. PMID 11513577.

[2] Hong, L., Turner, R.T., Koelsch, G., Shin, D., Ghosh, A.K. and Tang, J. (2002). „Crystal structure of memapsin 2 (β-secretase) in complex with an inhibitor OM00-3”. Biochemistry. 41: 10963—10967. PMID 12206667.

[1]

[2]