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Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Lipoksigenaza
Lipoksigenaza
Identifikatori
EC broj	1.13.11.12
CAS broj	9029-60-1
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Lipoksigenaza (EC 1.13.11.12, 13-lipoksidaza, karotenksa oksidaza, 13-lipoperoksidaza, masna oksidaza, 13-lipoksidaza, lionoleat:O2 13-oksidoreduktaza) je enzim sa sistematskim imenom linoleat:kiseonik 13-oksidoreduktaza.^[1]^[2]^[3]^[4]^[5] Ovaj enzim katalizuje sledeću hemijsku reakciju

(1) linoleat + O₂

\rightleftharpoons

(9Z,11E,13S)-13-hidroperoksioktadeka-9,11-dienoat

(2) alfa-linolenat + O₂

\rightleftharpoons

(9Z,11E,13S,15Z)-13-hidroperoksioktadeka-9,11,15-trienoat

Ovaj enzim sadrži nehemno gvožđe. Rasprostanjena biljna lipoksigenaza oksiduje linoleat i alfa-linolenat, dve najzastupljenije polinezasićene masne kiseline kod biljki, putem umetanja molekularnog kiseonika na C-13 poziciju (S)-konfiguracijom.

Reference

^ Christopher, J., Pistorius, E. and Axelrod, B. (1970). „Isolation of an enzyme of soybean lipoxidase”. Biochim. Biophys. Acta. 198: 12—19. PMID 5461103.
^ Theorell, H., Holman, R.T. and Åkesson, Å. (1947). „Crystalline lipoxidase”. Acta Chem. Scand. 1: 571—576. PMID 18907700.
^ Zimmerman, D.C. (1970). „Specificity of flaxseed lipoxidase”. Lipids. 5: 392—397. PMID 5447012.
^ Royo, J., Vancanneyt, G., Perez, A.G., Sanz, C., Stormann, K., Rosahl, S. and Sanchez-Serrano, J.J. (1996). „Characterization of three potato lipoxygenases with distinct enzymatic activities and different organ-specific and wound-regulated expression patterns”. J. Biol. Chem. 271: 21012—21019. PMID 8702864.
^ Bachmann, A., Hause, B., Maucher, H., Garbe, E., Voros, K., Weichert, H., Wasternack, C. and Feussner, I. (2002). „Jasmonate-induced lipid peroxidation in barley leaves initiated by distinct 13-LOX forms of chloroplasts”. Biol. Chem. 383: 1645—1657. PMID 12452441.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.

Spoljašnje veze

Linoleate+13S-lipoxygenase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Christopher, J., Pistorius, E. and Axelrod, B. (1970). „Isolation of an enzyme of soybean lipoxidase”. Biochim. Biophys. Acta. 198: 12—19. PMID 5461103.

[2] Theorell, H., Holman, R.T. and Åkesson, Å. (1947). „Crystalline lipoxidase”. Acta Chem. Scand. 1: 571—576. PMID 18907700.

[3] Zimmerman, D.C. (1970). „Specificity of flaxseed lipoxidase”. Lipids. 5: 392—397. PMID 5447012.

[4] Royo, J., Vancanneyt, G., Perez, A.G., Sanz, C., Stormann, K., Rosahl, S. and Sanchez-Serrano, J.J. (1996). „Characterization of three potato lipoxygenases with distinct enzymatic activities and different organ-specific and wound-regulated expression patterns”. J. Biol. Chem. 271: 21012—21019. PMID 8702864.

[5] Bachmann, A., Hause, B., Maucher, H., Garbe, E., Voros, K., Weichert, H., Wasternack, C. and Feussner, I. (2002). „Jasmonate-induced lipid peroxidation in barley leaves initiated by distinct 13-LOX forms of chloroplasts”. Biol. Chem. 383: 1645—1657. PMID 12452441.

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