Kofein sintaza

Kofein sintaza
Identifikatori
EC broj2.1.1.160
Baze podataka
IntEnzIntEnz pregled
BRENDABRENDA pristup
ExPASyNiceZyme pregled
KEGGKEGG pristup
MetaCycmetabolički put
PRIAMprofil
Strukture PBPRCSB PDB PDBe PDBj PDBsum

Kofein sintaza (EC 2.1.1.160, dimetilksantinska metiltransferaza, 3N-metiltransferaza, DXMT, CCS1, S-adenozil-L-metionin:3,7-dimetilksantin 1-N-metiltransferaza) je enzim sa sistematskim imenom S-adenozil-L-metionin:3,7-dimetilksantin N1-metiltransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju

(1) S-adenozil-L-metionin + 3,7-dimetilksantin S-adenozil-L-homocistein + 1,3,7-trimetilksantin
(2) S-adenozil-L-metionin + 1,7-dimetilksantin S-adenozil-L-homocistein + 1,3,7-trimetilksantin
(3) S-adenozil-L-metionin + 7-metilksantin S-adenozil-L-homocistein + 3,7-dimetilksantin

Paraksantin je najbolji supstrat ovog enzima.

Reference

  1. ^ Kato, M., Mizuno, K., Fujimura, T., Iwama, M., Irie, M., Crozier, A. and Ashihara, H. (1999). „Purification and characterization of caffeine synthase from tea leaves”. Plant Physiol. 120: 579—586. PMID 10364410. 
  2. ^ Mizuno, K., Okuda, A., Kato, M., Yoneyama, N., Tanaka, H., Ashihara, H. and Fujimura, T. (2003). „Isolation of a new dual-functional caffeine synthase gene encoding an enzyme for the conversion of 7-methylxanthine to caffeine from coffee (Coffea arabica L.)”. FEBS Lett. 534: 75—81. PMID 12527364. 
  3. ^ Uefuji, H., Ogita, S., Yamaguchi, Y., Koizumi, N. and Sano, H. (2003). „Molecular cloning and functional characterization of three distinct N-methyltransferases involved in the caffeine biosynthetic pathway in coffee plants”. Plant Physiol. 132: 372—380. PMID 12746542. 
  4. ^ Kato, M., Mizuno, K., Crozier, A., Fujimura, T. and Ashihara, H. (2000). „Caffeine synthase gene from tea leaves”. Nature. 406: 956—957. PMID 10984041. 

Literatura

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