PROFILPELAJAR.COM

Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Kobalt-prekorin-5B (C¹)-metiltransferaza
Kobalt-prekorin-5B (C1)-metiltransferaza
Identifikatori
EC broj	2.1.1.195
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Kobalt-prekorin-5B (C¹)-metiltransferaza (EC 2.1.1.195, kobalt-prekorin-6A sintaza, CbiD (gen)) je enzim sa sistematskim imenom S-adenozil-L-metionin:kobalt-prekorin-5B (C¹)-metiltransferaza.^[1]^[2] Ovaj enzim katalizuje sledeću hemijsku reakciju

kobalt-prekorin-5B + S-adenozil-L-metionin

\rightleftharpoons

kobalt-prekorin-6A + S-adenozil-L-homocistein

Ovaj enzim katalizuje C-1 metilaciju kobalt-prekorina-5B pri anaerobnoj biosintezi adenozilkobalamina.

Reference

^ Roper, J.M., Raux, E., Brindley, A.A., Schubert, H.L., Gharbia, S.E., Shah, H.N. and Warren, M.J. (2000). „The enigma of cobalamin (Vitamin B₁₂) biosynthesis in Porphyromonas gingivalis. Identification and characterization of a functional corrin pathway”. J. Biol. Chem. 275: 40316—40323. PMID 11007789.
^ Roessner, C.A., Williams, H.J. and Scott, A.I. (2005). „Genetically engineered production of 1-desmethylcobyrinic acid, 1-desmethylcobyrinic acid a,c-diamide, and cobyrinic acid a,c-diamide in Escherichia coli implies a role for CbiD in C-1 methylation in the anaerobic pathway to cobalamin”. J. Biol. Chem. 280: 16748—16753. PMID 15741157.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.

Spoljašnje veze

Cobalt-precorrin-5B+(C1)-methyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Roper, J.M., Raux, E., Brindley, A.A., Schubert, H.L., Gharbia, S.E., Shah, H.N. and Warren, M.J. (2000). „The enigma of cobalamin (Vitamin B₁₂) biosynthesis in Porphyromonas gingivalis. Identification and characterization of a functional corrin pathway”. J. Biol. Chem. 275: 40316—40323. PMID 11007789.

[2] Roessner, C.A., Williams, H.J. and Scott, A.I. (2005). „Genetically engineered production of 1-desmethylcobyrinic acid, 1-desmethylcobyrinic acid a,c-diamide, and cobyrinic acid a,c-diamide in Escherichia coli implies a role for CbiD in C-1 methylation in the anaerobic pathway to cobalamin”. J. Biol. Chem. 280: 16748—16753. PMID 15741157.

[1]

[2]

Kobalt-prekorin-5B (C1)-metiltransferaza

Reference

Literatura

Spoljašnje veze