Hidroliza rastvornog epoksida

Hidroliza rastvornog epoksida
Identifikatori
EC broj3.3.2.10
CAS broj9048-63-9
Baze podataka
IntEnzIntEnz pregled
BRENDABRENDA pristup
ExPASyNiceZyme pregled
KEGGKEGG pristup
MetaCycmetabolički put
PRIAMprofil
Strukture PBPRCSB PDB PDBe PDBj PDBsum

Hidroliza rastvornog epoksida (EC 3.3.2.10, epoksidna hidraza, epoksidna hidrataza, aren-oksidna hidrataza, aril epoksidna hidraza, trans-stilben oksidna hidrolaza, sEH, citozol epoksidna hidrolaza) je enzim sa sistematskim imenom epoksidna hidrolaza.[1][2][3][4][5][6][7][8][9][10] Ovaj enzim katalizuje sledeću hemijsku reakciju

epoksid + H2O glikol

Ovaj enzim katalizuje hidrolizu trans-supstituisanih epoksida, poput trans-stilbene oksida, kao i raznih alifatičnih epoksida izvedenih iz metabolizma masnih kiselina.

Reference

  1. ^ Newman, J.W., Morisseau, C., Harris, T.R. and Hammock, B.D. (2003). „The soluble epoxide hydrolase encoded by EPXH2 is a bifunctional enzyme with novel lipid phosphate phosphatase activity”. Proc. Natl. Acad. Sci. USA. 100: 1558—1563. PMID 12574510. 
  2. ^ Cronin, A., Mowbray, S., Dürk, H., Homburg, S., Fleming, I., Fisslthaler, B., Oesch, F. and Arand, M. (2003). „The N-terminal domain of mammalian soluble epoxide hydrolase is a phosphatase”. Proc. Natl. Acad. Sci. USA. 100: 1552—1557. PMID 12574508. 
  3. ^ Oesch, F. (1973). „Mammalian epoxide hydrases: inducible enzymes catalysing the inactivation of carcinogenic and cytotoxic metabolites derived from aromatic and olefinic compounds”. Xenobiotica. 3: 305—340. PMID 4584115. 
  4. ^ Morisseau, C. & Hammock, B.D. (2005). „Epoxide hydrolases: mechanisms, inhibitor designs, and biological roles”. Annu. Rev. Pharmacol. Toxicol. 45: 311—333. PMID 15822179. 
  5. ^ Yu, Z., Xu, F., Huse, L.M., Morisseau, C., Draper, A.J., Newman, J.W., Parker, C., Graham, L., Engler, M.M., Hammock, B.D., Zeldin, D.C. and Kroetz, D.L. (2000). „Soluble epoxide hydrolase regulates hydrolysis of vasoactive epoxyeicosatrienoic acids”. Circ. Res. 87: 992—998. PMID 11090543. 
  6. ^ Lacourciere, G.M. & Armstrong, R.N. (1993). „The catalytic mechanism of microsomal epoxide hydrolase involves an ester intermediate”. J. Am. Chem. Soc. 115: 10466—10456. 
  7. ^ Fretland, A.J. & Omiecinski, C.J. (2000). „Epoxide hydrolases: biochemistry and molecular biology”. Chem. Biol. Interact. 129: 41—59. PMID 11154734. 
  8. ^ Zeldin, D.C., Wei, S., Falck, J.R., Hammock, B.D., Snapper, J.R. and Capdevila, J.H. (1995). „Metabolism of epoxyeicosatrienoic acids by cytosolic epoxide hydrolase: substrate structural determinants of asymmetric catalysis”. Arch. Biochem. Biophys. 316: 443—451. PMID 7840649. 
  9. ^ Haeggström, J., Meijer, J. and Rådmark, O. (1986). „Leukotriene A4. Enzymatic conversion into 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid by mouse liver cytosolic epoxide hydrolase”. J. Biol. Chem. 261: 6332—6337. PMID 3009453. 
  10. ^ Newman, J.W., Morisseau, C. and Hammock, B.D. (2005). „Epoxide hydrolases: their roles and interactions with lipid metabolism”. Prog. Lipid Res. 44: 1—51. PMID 15748653. 

Literatura

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