Leukotrien-A4 hidrolaza

Leukotrien-A4 hidrolaza
Identifikatori
EC broj3.3.2.6
CAS broj90119-07-6
Baze podataka
IntEnzIntEnz pregled
BRENDABRENDA pristup
ExPASyNiceZyme pregled
KEGGKEGG pristup
MetaCycmetabolički put
PRIAMprofil
Strukture PBPRCSB PDB PDBe PDBj PDBsum

Leukotrien-A4 hidrolaza (EC 3.3.2.6, LTA4 hidrolaza, LTA4H, leukotrienska A4 hidrolaza) je enzim sa sistematskim imenom (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoksiikosa-7,9,11,14-tetraenoatna hidrolaza.[1][2][3][4][5][6][7] Ovaj enzim katalizuje sledeću hemijsku reakciju

leukotrien A4 + H2O leukotrien B4

Ova bifunkcionalna cinkova metaloproteaza deluje kao epoksidna hidrolaza i aminopeptidaza.

Reference

  1. ^ Evans, J.F., Dupuis, P. and Ford-Hutchinson, A.W. (1985). „Purification and characterisation of leukotriene A4 hydrolase from rat neutrophils”. Biochim. Biophys. Acta. 840: 43—50. PMID 3995081. 
  2. ^ Minami, M., Ohno, S., Kawasaki, H., Rådmark, O., Samuelsson, B., Jörnvall, H., Shimizu, T., Seyama, Y. and Suzuki, K. (1987). „Molecular cloning of a cDNA coding for human leukotriene A4 hydrolase - complete primary structure of an enzyme involved in eicosanoid synthesis”. J. Biol. Chem. 262: 13873—13876. PMID 3654641. 
  3. ^ Haeggström, J., Meijer, J. and Rådmark, O. (1986). „Leukotriene A4. Enzymatic conversion into 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid by mouse liver cytosolic epoxide hydrolase”. J. Biol. Chem. 261: 6332—6337. PMID 3009453. 
  4. ^ Newman, J.W., Morisseau, C. and Hammock, B.D. (2005). „Epoxide hydrolases: their roles and interactions with lipid metabolism”. Prog. Lipid Res. 44: 1—51. PMID 15748653. 
  5. ^ Fretland, A.J. & Omiecinski, C.J. (2000). „Epoxide hydrolases: biochemistry and molecular biology”. Chem. Biol. Interact. 129: 41—59. PMID 11154734. 
  6. ^ Orning, L., Gierse, J.K. and Fitzpatrick, F.A. (1994). „The bifunctional enzyme leukotriene-A4 hydrolase is an arginine aminopeptidase of high efficiency and specificity”. J. Biol. Chem. 269: 11269—11267. PMID 8157657. 
  7. ^ Ohishi, N., Izumi, T., Minami, M., Kitamura, S., Seyama, Y., Ohkawa, S., Terao, S., Yotsumoto, H., Takaku, F. and Shimizu, T. (1987). „Leukotriene A4 hydrolase in the human lung. Inactivation of the enzyme with leukotriene A4 isomers”. J. Biol. Chem. 262: 10200—10205. PMID 3038871. 

Literatura

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