GNA12

Guanin nukleotid-vezujući protein (G protein), alfa 12
PDB prikaz baziran na 1zca.
Dostupne strukture
1zca​
Identifikatori
Simboli GNA12; RMP; MGC104623; MGC99644; NNX3; gep
Vanjski ID OMIM: 604394 MGI: 95767 HomoloGene: 22398 GeneCards: GNA12 Gene
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 2768 14673
Ensembl ENSG00000146535 ENSMUSG00000000149
UniProt Q03113 Q2NKI3
RefSeq (mRNA) NM_007353 XM_001001104
RefSeq (protein) NP_031379 XP_001001104
Lokacija (UCSC) Chr 7:
2.73 - 2.85 Mb		 Chr 5:
141.01 - 141.08 Mb
PubMed pretraga [1] [2]

GNA12, Guanin nukleotid-vezujući protein alfa 12, je protein koji je kod ljudi kodiran GNA12 genom.[1][2][3]

Interakcije

Za GNA12 je bilo pokazano da interaguje sa ARHGEF1, PPP5C,[4] ARHGEF12,[5][6] citosolinim proteinom toplotnog udara 90 kDa alfa, članom A1[7] i TEC.[6]

Reference

  1. ^ Chan AM; Fleming TP; McGovern ES; Chedid M; Miki T; Stuart A. Aaronson (1993). „Expression cDNA cloning of a transforming gene encoding the wild-type G alpha 12 gene product”. Mol Cell Biol. 13 (2): 762—8. PMC 358958 Слободан приступ. PMID 8423800. 
  2. ^ Kumar RN, Shore SK, Dhanasekaran N (2006). „Neoplastic transformation by the gep oncogene, Galpha12, involves signaling by STAT3”. Oncogene. 25 (6): 899—906. PMID 16247467. doi:10.1038/sj.onc.1209132. 
  3. ^ „Entrez Gene: GNA12 guanine nucleotide binding protein (G protein) alpha 12”. 
  4. ^ Yamaguchi, Yoshiaki; Katoh Hironori; et al. (2002). „Galpha(12) and Galpha(13) interact with Ser/Thr protein phosphatase type 5 and stimulate its phosphatase activity”. Curr. Biol. England. 12 (15): 1353—8. ISSN 0960-9822. PMID 12176367. doi:10.1016/S0960-9822(02)01034-5. 
  5. ^ Fukuhara, S; Chikumi H; Gutkind J S (2000). „Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho”. FEBS Lett. NETHERLANDS. 485 (2-3): 183—8. ISSN 0014-5793. PMID 11094164. doi:10.1016/S0014-5793(00)02224-9. 
  6. ^ а б Suzuki, Nobuchika; Nakamura Susumu; et al. (2003). „Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF”. Proc. Natl. Acad. Sci. U.S.A. United States. 100 (2): 733—8. ISSN 0027-8424. PMC 141065 Слободан приступ. PMID 12515866. doi:10.1073/pnas.0234057100. 
  7. ^ Vaiskunaite, R; Kozasa T; Voyno-Yasenetskaya T A (2001). „Interaction between the G alpha subunit of heterotrimeric G(12) protein and Hsp90 is required for G alpha(12) signaling”. J. Biol. Chem. United States. 276 (49): 46088—93. ISSN 0021-9258. PMID 11598136. doi:10.1074/jbc.M108711200. 

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