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Dimetilamin-korinoid protein Co-metiltransferaza
Dimetilamin-korinoid protein Co-metiltransferaza
Identifikatori
EC broj	2.1.1.249
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
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NCBI	proteini

Dimetilamin-korinoid protein Co-metiltransferaza (EC 2.1.1.249, mtbB (gen), dimetilaminska metiltransferaza) je enzim sa sistematskim imenom dimetilamin:5-hidroksibenzimidazolilkobamid Co-metiltransferaza.^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

dimetilamin + [Co(I) dimetilamin-specifični korinoidni protein]

\rightleftharpoons

[metil-Co(III) dimetilamin-specifični korinoidni protein] + metilamin

Enzim, koji katalizuje transfer metil grupe sa dimetilamina na dimetilamin-specifični korinoidni protein (MtbC), učestvuje u metanogenezi. Ovaj enzim sadrži neobičnu aminokiselinu pirolizin.

Reference

^ Wassenaar, R.W., Keltjens, J.T., van der Drift, C. and Vogels, G.D. (1998). „Purification and characterization of dimethylamine:5-hydroxybenzimidazolyl-cobamide methyltransferase from Methanosarcina barkeri Fusaro”. Eur. J. Biochem. 253: 692—697. PMID 9654067.
^ Ferguson, D.J., Jr., Gorlatova, N., Grahame, D.A. and Krzycki, J.A. (2000). „Reconstitution of dimethylamine:coenzyme M methyl transfer with a discrete corrinoid protein and two methyltransferases purified from Methanosarcina barkeri”. J. Biol. Chem. 275: 29053—29060. PMID 10852929.
^ Krzycki, J.A. (2004). „Function of genetically encoded pyrrolysine in corrinoid-dependent methylamine methyltransferases”. Curr. Opin. Chem. Biol. 8: 484—491. PMID 15450490.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.

Spoljašnje veze

Dimethylamine---corrinoid+protein+Co-methyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Wassenaar, R.W., Keltjens, J.T., van der Drift, C. and Vogels, G.D. (1998). „Purification and characterization of dimethylamine:5-hydroxybenzimidazolyl-cobamide methyltransferase from Methanosarcina barkeri Fusaro”. Eur. J. Biochem. 253: 692—697. PMID 9654067.

[2] Ferguson, D.J., Jr., Gorlatova, N., Grahame, D.A. and Krzycki, J.A. (2000). „Reconstitution of dimethylamine:coenzyme M methyl transfer with a discrete corrinoid protein and two methyltransferases purified from Methanosarcina barkeri”. J. Biol. Chem. 275: 29053—29060. PMID 10852929.

[3] Krzycki, J.A. (2004). „Function of genetically encoded pyrrolysine in corrinoid-dependent methylamine methyltransferases”. Curr. Opin. Chem. Biol. 8: 484—491. PMID 15450490.

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