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PubMed	članci
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Demetilrebekamicin-D-glukoza O-metiltransferaza
Demetilrebekamicin-D-glukoza O-metiltransferaza
Identifikatori
EC broj	2.1.1.164
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
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NCBI	proteini

Demetilrebekamicin-D-glukoza O-metiltransferaza (EC 2.1.1.164, RebM) je enzim sa sistematskim imenom S-adenozil-L-metionin:demetilrebekamicin-D-glukoza O-metiltransferaza.^[1]^[2] Ovaj enzim katalizuje sledeću hemijsku reakciju

4'-demetilrebekmicin + S-adenozil-L-metionin

\rightleftharpoons

rebekamicin + S-adenozil-L-homocistein

Ovaj enzim katalizuje zadnji korak biosinteze rebekamicina, indolokarbazolnog alkaloida koji formira actinobakterija Lechevalieria aerocolonigenes.

Reference

^ Zhang, C., Albermann, C., Fu, X., Peters, N.R., Chisholm, J.D., Zhang, G., Gilbert, E.J., Wang, P.G., Van Vranken, D.L. and Thorson, J.S. (2006). „RebG- and RebM-catalyzed indolocarbazole diversification”. Chembiochem. 7: 795—804. PMID 16575939.
^ Singh, S., McCoy, J.G., Zhang, C., Bingman, C.A., Phillips, G.N., Jr. and Thorson, J.S. (2008). „Structure and mechanism of the rebeccamycin sugar 4′-O-methyltransferase RebM”. J. Biol. Chem. 283: 22628—22636. PMID 18502766.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.

Spoljašnje veze

Demethylrebeccamycin-D-glucose+O-methyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Zhang, C., Albermann, C., Fu, X., Peters, N.R., Chisholm, J.D., Zhang, G., Gilbert, E.J., Wang, P.G., Van Vranken, D.L. and Thorson, J.S. (2006). „RebG- and RebM-catalyzed indolocarbazole diversification”. Chembiochem. 7: 795—804. PMID 16575939.

[2] Singh, S., McCoy, J.G., Zhang, C., Bingman, C.A., Phillips, G.N., Jr. and Thorson, J.S. (2008). „Structure and mechanism of the rebeccamycin sugar 4′-O-methyltransferase RebM”. J. Biol. Chem. 283: 22628—22636. PMID 18502766.

[1]

[2]