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Demetilmakrocin O-metiltransferaza
Demetilmakrocin O-metiltransferaza
Identifikatori
EC broj	2.1.1.102
CAS broj	120313-64-6
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
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Demetilmakrocin O-metiltransferaza (EC 2.1.1.102, demetilmakrocinska metiltransferaza) je enzim sa sistematskim imenom S-adenozil-L-metionin:demetilmakrocin 2'-O-metiltransferaza.^[1] Ovaj enzim katalizuje sledeću hemijsku reakciju

S-adenozil-L-metionin + demetilmakrocin

\rightleftharpoons

S-adenozil-L-homocistein + makrocin

2-Hidroksi grupa ostatka 6-dezoksi-D-aloznog ostatka u demetilmakrocinu deluje kao metilni akceptor.

Reference

^ Kreuzman, A.J., Turner, J.R. and Yeh, W.-K. (1988). „Two distinctive O-methyltransferases catalyzing penultimate and terminal reactions of macrolide antibiotic (tylosin) biosynthesis. Substrate specificity, enzyme inhibition, and kinetic mechanism”. J. Biol. Chem. 263: 15626—15633. PMID 3170602.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.

Spoljašnje veze

Demethylmacrocin+O-methyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Kreuzman, A.J., Turner, J.R. and Yeh, W.-K. (1988). „Two distinctive O-methyltransferases catalyzing penultimate and terminal reactions of macrolide antibiotic (tylosin) biosynthesis. Substrate specificity, enzyme inhibition, and kinetic mechanism”. J. Biol. Chem. 263: 15626—15633. PMID 3170602.

[1]