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DTDP-3-amino-3,4,6-tridezoksi-alfa-D-glukopiranoza N,N-dimetiltransferaza
DTDP-3-amino-3,4,6-tridezoksi-alfa-D-glukopiranoza N,N-dimetiltransferaza
Identifikatori
EC broj	2.1.1.234
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
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NCBI	proteini

DTDP-3-amino-3,4,6-tridezoksi-alfa-D-glukopiranoza N,N-dimetiltransferaza (EC 2.1.1.234, DesVI) je enzim sa sistematskim imenom S-adenozil-L-metionin:dTDP-3-amino-3,4,6-tridezoksi-alfa-D-glukopiranoza 3-N,N-dimetiltransferaza.^[1]^[2] Ovaj enzim katalizuje sledeću hemijsku reakciju

2 S-adenozil-L-metionin + dTDP-3-amino-3,4,6-tridezoksi-alfa-D-glukopiranoza

\rightleftharpoons

2 S-adenozil-L-homocistein + dTDP-3-dimetilamino-3,4,6-tridezoksi-alfa-D-glukopiranoza

Ovaj enzim učestvuje u biosintezi desosamina, 3-(dimetilamino)-3,4,6-tridezoksiheksoze prisutne u pojedinim makrolidnim antibioticima kao što je ertiromicin, azitromicin, i klaritromicin.

Reference

^ Chen, H., Yamase, H., Murakami, K., Chang, C.W., Zhao, L., Zhao, Z. and Liu, H.W. (2002). „Expression, purification, and characterization of two N,N-dimethyltransferases, tylM1 and desVI, involved in the biosynthesis of mycaminose and desosamine”. Biochemistry. 41: 9165—9183. PMID 12119032.
^ Burgie, E.S. & Holden, H.M. (2008). „Three-dimensional structure of DesVI from Streptomyces venezuelae: a sugar N,N-dimethyltransferase required for dTDP-desosamine biosynthesis”. Biochemistry. 47: 3982—3988. PMID 18327916.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.

Spoljašnje veze

DTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose+N,N-dimethyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Chen, H., Yamase, H., Murakami, K., Chang, C.W., Zhao, L., Zhao, Z. and Liu, H.W. (2002). „Expression, purification, and characterization of two N,N-dimethyltransferases, tylM1 and desVI, involved in the biosynthesis of mycaminose and desosamine”. Biochemistry. 41: 9165—9183. PMID 12119032.

[2] Burgie, E.S. & Holden, H.M. (2008). „Three-dimensional structure of DesVI from Streptomyces venezuelae: a sugar N,N-dimethyltransferase required for dTDP-desosamine biosynthesis”. Biochemistry. 47: 3982—3988. PMID 18327916.

[1]

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