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PubMed	članci
NCBI	proteini

D-alanin—(R)-laktat ligaza
D-alanin—(R)-laktat ligaza
Identifikatori
EC broj	6.1.2.1
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

D-alanin—(R)-laktat ligaza (EC 6.1.2.1, VanA, VanB, VanD) je enzim sa sistematskim imenom D-alanin:(R)-laktat ligaza (formira ADP).^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

D-alanin + (R)-laktat + ATP

\rightleftharpoons

D-alanil-(R)-laktat + ADP + fosfat

Produkt ovog enzim može da bude inkorporisan u peptidoglikan pentapeptid umesto u uobičajeni D-alanil-D-alanin dipeptid.

Reference

^ Bugg, T.D., Wright, G.D., Dutka-Malen, S., Arthur, M., Courvalin, P. and Walsh, C.T. (1991). „Molecular basis for vancomycin resistance in Enterococcus faecium BM4147: biosynthesis of a depsipeptide peptidoglycan precursor by vancomycin resistance proteins VanH and VanA”. Biochemistry. 30: 10408—10415. PMID 1931965.
^ Meziane-Cherif, D., Badet-Denisot, M.A., Evers, S., Courvalin, P. and Badet, B. (1994). „Purification and characterization of the VanB ligase associated with type B vancomycin resistance in Enterococcus faecalis V583”. FEBS Lett. 354: 140—142. PMID 7957913.
^ Perichon, B., Reynolds, P. and Courvalin, P. (1997). „VanD-type glycopeptide-resistant Enterococcus faecium BM4339”. Antimicrob. Agents Chemother. 41: 2016—2018. PMID 9303405.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.

Spoljašnje veze

D-alanine-(R)-lactate+ligase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Bugg, T.D., Wright, G.D., Dutka-Malen, S., Arthur, M., Courvalin, P. and Walsh, C.T. (1991). „Molecular basis for vancomycin resistance in Enterococcus faecium BM4147: biosynthesis of a depsipeptide peptidoglycan precursor by vancomycin resistance proteins VanH and VanA”. Biochemistry. 30: 10408—10415. PMID 1931965.

[2] Meziane-Cherif, D., Badet-Denisot, M.A., Evers, S., Courvalin, P. and Badet, B. (1994). „Purification and characterization of the VanB ligase associated with type B vancomycin resistance in Enterococcus faecalis V583”. FEBS Lett. 354: 140—142. PMID 7957913.

[3] Perichon, B., Reynolds, P. and Courvalin, P. (1997). „VanD-type glycopeptide-resistant Enterococcus faecium BM4339”. Antimicrob. Agents Chemother. 41: 2016—2018. PMID 9303405.

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