COX-2 gen miša je klonirao UCLA naučnik dr. Harvi Herčman.[1] Enzim je otkrio 1988. Danijel Simons.[2] On je odmah uvideo značaj svog otkrića, te je istog dana odredio sekvencu enzima. Naknadno je kompanija Pfizer, sa kojom je Simons imao ugovor, navodno raskinula ugovor i odbila ispoštuje njegova autorska prava, iz kog razloga je usledio dugotrajni sudski spor.[3][4]
Reference
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Montero Fernández MJ, Rodríguez Alcalá FJ, Valles Fernández N, López de Castro F, Esteban Tudela M, Cordero García B (2002). „[At what care level are cyclo-oxygenase-2 inhibitors prescribed?]”. Aten Primaria (на језику: Spanish; Castilian). 30 (6): 363—7. PMID12396942. Архивирано из оригинала 08. 07. 2007. г. Приступљено 23. 01. 2012.CS1 одржавање: Непрепознат језик (веза)
"You and A: Arthritis drugs. Pain and confusion"; Francesca Lunzer Kritz; Washington Post; Sept. 4, 2001; HE01.
"Vioxx (rofecoxib) reduces night-time osteoarthritis pain better than celecoxib or acetaminophen"; European League Against Rheumatism (EULAR) conference proceedings.
"Will the promise of the COX-II selective NSAIDs come to fruition?"; Drug Ther Perspect 17(11); 6-10, 2001.
Chancellor JV, Hunsche E, de Cruz E, Sarasin FP (2001). „Economic evaluation of celecoxib, a new cyclo-oxygenase 2 specific inhibitor, in Switzerland”. Pharmacoeconomics. 19 Suppl 1: 59—75. PMID11280106. doi:10.2165/00019053-200119001-00005.
Kamath CC, Kremers HM, Vanness DJ, O'Fallon WM, Cabanela RL, Gabriel SE (2003). „The cost-effectiveness of acetaminophen, NSAIDs, and selective COX-2 inhibitors in the treatment of symptomatic knee osteoarthritis”. Value Health. 6 (2): 144—57. PMID12641865. doi:10.1046/j.1524-4733.2003.00215.x.
"Osteoarthritis drug Celebrex (celecoxib) less likely to cause increased blood pressure than Vioxx (rofecoxib)"; European League Against Rheumatism (EULAR) conference proceedings.
Johnsen JI; Lindskog M; Ponthan F; et al. (2004). „Cyclooxygenase-2 is expressed in neuroblastoma, and nonsteroidal anti-inflammatory drugs induce apoptosis and inhibit tumor growth in vivo”. Cancer Res. 64 (20): 7210—5. PMID15492235. doi:10.1158/0008-5472.CAN-04-1795.CS1 одржавање: Експлицитна употреба et al. (веза)