Azot monoksid reduktaza (citohrom c)

Azot monoksid reduktaza (citohrom c)
Identifikatori
EC broj1.7.2.5
Baze podataka
IntEnzIntEnz pregled
BRENDABRENDA pristup
ExPASyNiceZyme pregled
KEGGKEGG pristup
MetaCycmetabolički put
PRIAMprofil
Strukture PBPRCSB PDB PDBe PDBj PDBsum

Azot monoksid reduktaza (citohrom c) (EC 1.7.2.5, Azot monoksidna reduktaza (citohrom c)) je enzim sa sistematskim imenom azot monoksid:fericitohrom-c oksidoreduktaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju:

azotsuboksid + 2 fericitohrom c +H2O 2 azot monoksid + 2 ferocitohrom c + 2 H+

Enzim iz Pseudomonas aeruginosa sadrži dinuklearni centar koji obuhvata nehemni centar gvožđa i hem b3, plus hem c, hem b i kalcijum. Akceptor je citohrom c551.

Reference

  1. ^ Hendriks, J., Warne, A., Gohlke, U., Haltia, T., Ludovici, C., Lubben, M. and Saraste, M. (1998). „The active site of the bacterial nitric oxide reductase is a dinuclear iron center”. Biochemistry. 37: 13102—13109. PMID 9748316. 
  2. ^ Hendriks, J., Gohlke, U. and Saraste, M. (1998). „From NO to OO: nitric oxide and dioxygen in bacterial respiration”. J. Bioenerg. Biomembr. 30: 15—24. PMID 9623801. 
  3. ^ Heiss, B., Frunzke, K. and Zumpft, W.G. (1989). „Formation of the N-N bond from nitric oxide by a membrane-bound cytochrome bc complex of nitrate-respiring (denitrifying) Pseudomonas stutzeri”. J. Bacteriol. 171: 3288—3297. PMID 2542222. 
  4. ^ Cheesman, M.R., Zumft, W.G. and Thomson, A.J. (1998). „The MCD and EPR of the heme centers of nitric oxide reductase from Pseudomonas stutzeri: evidence that the enzyme is structurally related to the heme-copper oxidases”. Biochemistry. 37: 3994—4000. PMID 9521721. 
  5. ^ Kumita, H., Matsuura, K., Hino, T., Takahashi, S., Hori, H., Fukumori, Y., Morishima, I. and Shiro, Y. (2004). „NO reduction by nitric-oxide reductase from denitrifying bacterium Pseudomonas aeruginosa: characterization of reaction intermediates that appear in the single turnover cycle”. J. Biol. Chem. 279: 55247—55254. PMID 15504726. 
  6. ^ Hino, T., Matsumoto, Y., Nagano, S., Sugimoto, H., Fukumori, Y., Murata, T., Iwata, S. and Shiro, Y. (2010). „Structural basis of biological N2O generation by bacterial nitric oxide reductase”. Science. 330: 1666—1670. PMID 21109633. 

Literatura

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