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Urat oksidaza
Urat oksidaza
	Urat oksidaza tetramer, Aspergillus flavus
Identifikatori
EC broj	1.7.3.3
CAS broj	2594291
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
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NCBI	proteini

Urat oksidaza (EC 1.7.3.3, urinsko kiselinska oksidaza, urikaza, urikaza II, uratna-oksidaza) je enzim sa sistematskim imenom urat:kiseonik oksidoreduktaza.^[1]^[2]^[3]^[4]^[5]^[6] Ovaj enzim katalizuje sledeću hemijsku reakciju

urat + O₂ +H₂O

\rightleftharpoons

5-hidroksiizourat +H₂O₂

Enzimu iz zrna soje, plesni Aspergillus flavus i Bacillus subtilis ne sadrže bakar, niti druge jone prelaznih metala.

Reference

^ London, M. & Hudson, P.B. (1956). „Purification and properties of solubilized uricase”. Biochim. Biophys. Acta. 21: 290—298. PMID 13363909.
^ Mahler, H.R., Hübscher, G. and Baum, H. (1955). „Studies on uricase. I. Preparation, purification, and properties of a cuproprotein”. J. Biol. Chem. 216: 625—641. PMID 13271340.
^ Robbins, K.C., Barnett, E.L. and Grant, N.H. (1955). „Partial purification of porcine liver uricase”. J. Biol. Chem. 216: 27—35. PMID 13252004.
^ Kahn, K. & Tipton, P.A. (1998). „Spectroscopic characterization of intermediates in the urate oxidase reaction”. Biochemistry. 37: 11651—11659. PMID 9709003.
^ Colloc'h, N., el Hajji, M., Bachet, B., L'Hermite, G., Schiltz, M., Prange, T., Castro, B. and Mornon, J.-P. (1997). „Crystal structure of the protein drug urate oxidase-inhibitor complex at 2.05 Å resolution”. Nat. Struct. Biol. 4: 947—952. PMID 9360612.
^ Imhoff, R.D., Power, N.P., Borrok, M.J. and Tipton, P.A. (2003). „General base catalysis in the urate oxidase reaction: evidence for a novel Thr-Lys catalytic diad”. Biochemistry. 42: 4094—4100. PMID 12680763.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.

Spoljašnje veze

Urate+oxidase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] London, M. & Hudson, P.B. (1956). „Purification and properties of solubilized uricase”. Biochim. Biophys. Acta. 21: 290—298. PMID 13363909.

[2] Mahler, H.R., Hübscher, G. and Baum, H. (1955). „Studies on uricase. I. Preparation, purification, and properties of a cuproprotein”. J. Biol. Chem. 216: 625—641. PMID 13271340.

[3] Robbins, K.C., Barnett, E.L. and Grant, N.H. (1955). „Partial purification of porcine liver uricase”. J. Biol. Chem. 216: 27—35. PMID 13252004.

[4] Kahn, K. & Tipton, P.A. (1998). „Spectroscopic characterization of intermediates in the urate oxidase reaction”. Biochemistry. 37: 11651—11659. PMID 9709003.

[5] Colloc'h, N., el Hajji, M., Bachet, B., L'Hermite, G., Schiltz, M., Prange, T., Castro, B. and Mornon, J.-P. (1997). „Crystal structure of the protein drug urate oxidase-inhibitor complex at 2.05 Å resolution”. Nat. Struct. Biol. 4: 947—952. PMID 9360612.

[6] Imhoff, R.D., Power, N.P., Borrok, M.J. and Tipton, P.A. (2003). „General base catalysis in the urate oxidase reaction: evidence for a novel Thr-Lys catalytic diad”. Biochemistry. 42: 4094—4100. PMID 12680763.

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