Abl (gen)

ABL proto-onkogen 1, nereceptorska tirozinska kinaza
PDB prikaz baziran na 1ab2.
Dostupne strukture
1AB2​, 1ABL​, 1AWO​, 1BBZ​, 1JU5​, 1OPL​, 1ZZP​, 2ABL​, 2E2B​, 2F4J​, 2FO0​, 2G1T​, 2G2F​, 2G2H​, 2G2I​, 2GQG​, 2HIW​, 2HYY​, 2HZ0​, 2HZ4​, 2HZI​, 2O88​, 2V7A​, 3CS9​, 3EG0​, 3EG1​, 3EG2​, 3EG3​, 3EGU​, 3K2M​, 3PYY​, 3QRI​, 3QRJ​, 3QRK​, 3T04​, 3UE4​, 3UYO​, 4J9B​, 4J9C​, 4J9D​, 4J9E​, 4J9F​, 4J9G​, 4J9H​, 4J9I​, 4JJB​, 4JJC​, 4JJD​
Identifikatori
Simboli ABL1; ABL; JTK7; bcr/abl; c-ABL; c-ABL1; p150; v-abl
Vanjski ID OMIM: 189980 MGI: 87859 HomoloGene: 3783 GeneCards: ABL1 Gene
EC broj 2.7.10.2
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 25 11350
Ensembl ENSG00000097007 ENSMUSG00000026842
UniProt P00519 P00520
RefSeq (mRNA) NM_005157 NM_001112703
RefSeq (protein) NP_005148 NP_001106174
Lokacija (UCSC) Chr 9:
133.59 - 133.76 Mb		 Chr 2:
31.69 - 31.8 Mb
PubMed pretraga [1] [2]

Abelsonov mišji leukemijski viralni onkogen homolog 1 (ABL1) protein je koji je kod ljudi kodiran ABL1 genom (raniji simbol ABL) lociranim na hromozomu 9.[1] c-Abl se ponekad koristi za imenovanje verzije gena prisutnog u genomu sisara, dok se v-Abl odnosi na viralni gen.

Interakcije

Abl gen formira interakcije sa:

Regulacija

Postoje izvesni dokazi da je izražavanje Abl regulisano posredstvom mikroRNK miR-203.[50]

Vidi još

Reference

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Literatura

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