Src (gen)

V-src sarkoma viralni onkogeni homolog (avijarni)
PDB prikaz baziran na 1a07​.
Dostupne strukture
1a07​, 1a08​, 1a09​, 1a1a​, 1a1b​, 1a1c​, 1a1e​, 1bkl​, 1bkm​, 1f1w​, 1f2f​, 1fmk​, 1hcs​, 1hct​, 1is0​, 1kc2​, 1ksw​, 1nlo​, 1nlp​, 1nzl​, 1nzv​, 1o41​, 1o42​, 1o43​, 1o44​, 1o45​, 1o46​, 1o47​, 1o48​, 1o49​, 1o4a​, 1o4b​, 1o4c​, 1o4d​, 1o4e​, 1o4f​, 1o4g​, 1o4h​, 1o4i​, 1o4j​, 1o4k​, 1o4l​, 1o4m​, 1o4n​, 1o4o​, 1o4p​, 1o4q​, 1o4r​, 1p13​, 1prl​, 1prm​, 1qwe​, 1qwf​, 1rlp​, 1rlq​, 1sha​, 1shb​, 1shd​, 1skj​, 1spr​, 1sps​, 1srl​, 1srm​, 1y57​, 1yi6​, 1yoj​, 1yol​, 1yom​, 2bdf​, 2bdj​, 2h8h​, 2hwo​, 2hwp​, 2oiq​, 2ptk​, 2src​
Identifikatori
Simboli SRC; ASV; SRC1; c-SRC; p60-Src
Vanjski ID OMIM: 190090 MGI: 98397 HomoloGene: 21120 GeneCards: SRC Gene
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 6714 20779
Ensembl ENSG00000197122 ENSMUSG00000027646
UniProt P12931 Q2M4I4
RefSeq (mRNA) NM_005417 NM_001025395
RefSeq (protein) NP_005408 NP_001020566
Lokacija (UCSC) Chr 20:
35.41 - 35.47 Mb		 Chr 2:
157.12 - 157.16 Mb
PubMed pretraga [1] [2]

Src je proto-onkogenska tirozinska kinaza. Src su otkrili Mihael Bišop i Harold Varmus. Za ovo otkriće im je dodeljena Nobelova nagrada za fiziologiju ili medicinu 1989. godine.[1] Ova kinaza pripada familiji nespecifičnih proteinskih tirozinskih kinaza koja se naziva Src familijom kinaza. Otkriće Src porodice proteina je imalo presudnu ulogu u modernom shvatanju rak kao bolesti u kojoj se inače zdrava ćelijska signalizacija pokvari.

Ovaj gen je sličan sa v-src genom Rous sarkoma virusa. Ovaj proto-onkogen može da igra ulogu u regulisanju embrionalnog razvoja i rasta ćelija. Proteinska kinaza koju ovaj gen kodira se može inhibirati fosforilacijom c-SRC kinazom. Mutacije ovog gena mogu da učestvuju u malignom razvoju raka debelog creva. Dve transkriptne varijante koje kodiraju isti protein su nađene za ovaj gen.[2]

Interactions

Za Src gen je bilo pokazano da interaguje sa GRIN2A,[3][4] C-Raf,[5] CD44,[6] Jedreni translokator arilnog ugljovodoničnog receptora,[7] Aryl hydrocarbon receptor,[7] PDE6G,[8] STAT1,[9][10] EPH receptor B2,[11][12] Androgenski receptor,[13][14][15] Proteinska kinaza Mζ,[16] STAT3,[17] Grb2,[8][18] Beta-3 adrenergički receptor,[19] Kinaza beta adrenergičkog receptora,[8] Receptor epidermalnog faktora rasta,[9][20][21] PTK2,[22][23][24][25][26][27] DAB2,[28] EPS8,[29] Distroglikan,[30] Estrogenski receptor alfa,[13][31][32][33] Estrogenski receptor beta,[13][33] HNF1A,[34] KHDRBS1,[35][36][37][38][39] DDEF1,[40] MUC1,[41][42] PTK2B,[20][43][44] BCAR1,[45][22][46][47][48][24] SHB,[49] PLD2,[50] Faktor responsa seruma,[51] NCOA6,[52][53][54][55] Receptor retinoiske kiseline alfa,[32][56] Protein Viskot-Oldrić sindroma,[57][58] RICS,[59] RAS p21 proteinski activator 1,[60][61] MT-ND2[62] i GNB2L1.[63]

Reference

  1. ^ Nobel Prize in Physiology or Medicine for 1989 jointly to J. Michael Bishop and Harold E. Varmus for their discovery of "the cellular origin of retroviral oncogenes". Press Release.
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  3. ^ Ma, Juan; Zhang Guang-Yi (2003). „Lithium reduced N-methyl-D-aspartate receptor subunit 2A tyrosine phosphorylation and its interactions with Src and Fyn mediated by PSD-95 in rat hippocampus following cerebral ischemia”. Neurosci. Lett. Ireland. 348 (3): 185—9. ISSN 0304-3940. PMID 12932824. doi:10.1016/S0304-3940(03)00784-5. 
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  62. ^ Gingrich, Jeffrey R; et al. (2004). „Unique domain anchoring of Src to synaptic NMDA receptors via the mitochondrial protein NADH dehydrogenase subunit 2”. Proc. Natl. Acad. Sci. U.S.A. United States. 101 (16): 6237—42. ISSN 0027-8424. PMC 395953 Слободан приступ. PMID 15069201. doi:10.1073/pnas.0401413101. 
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Literatura

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