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3a,7a-dihidroksi-5b-holestanat-KoA ligaza
3a,7a-dihidroksi-5b-holestanat-KoA ligaza
Identifikatori
EC broj	6.2.1.28
CAS broj	118732-03-9
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IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
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3a,7a-dihidroksi-5b-holestanat-KoA ligaza (EC 6.2.1.28, 3alfa,7alfa-dihidroksi-5beta-holestanoil koenzim A sintetaza, DHCA-KoA ligaza, 3alfa,7alfa-dihidroksi-5beta-holestanat:KoA ligaza (formira AMP)) je enzim sa sistematskim imenom (25R)-3alfa,7alfa-dihidroksi-5beta-holestan-26-oat:KoA ligaza (formira AMP).^[1] Ovaj enzim katalizuje sledeću hemijsku reakciju

ATP + (25R)-3alfa,7alfa-dihidroksi-5beta-holestan-26-oat + KoA

\rightleftharpoons

AMP + difosfat + (25R)-3alfa,7alfa-dihidroksi-5beta-holestanoil-KoA

Reference

^ Prydz, K., Kase, B.F., Björkhem, I. and Pedersen, J.I. (1988). „Subcellular localization of 3α,7α-dihydroxy- and 3α,7α,12α-trihydroxy-5β-cholestanoyl-coenzyme A ligase(s) in rat liver”. J. Lipid Res. 29: 997—1004. PMID 3183523.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.

Spoljašnje veze

3alpha,7alpha-dihydroxy-5beta-cholestanate-CoA+ligase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Prydz, K., Kase, B.F., Björkhem, I. and Pedersen, J.I. (1988). „Subcellular localization of 3α,7α-dihydroxy- and 3α,7α,12α-trihydroxy-5β-cholestanoyl-coenzyme A ligase(s) in rat liver”. J. Lipid Res. 29: 997—1004. PMID 3183523.

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