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3-dehidrohinat sintaza II
3-dehidrohinat sintaza II
Identifikatori
EC broj	1.4.1.24
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
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NCBI	proteini

3-dehidrohinat sintaza II (EC 1.4.1.24, DHQ sintaza II, MJ1249 (gen), aroB' (gen)) je enzim sa sistematskim imenom 2-amino-3,7-didezoksi-D-treo-hept-6-ulozonat:NAD⁺ oksidoreduktaza (deaminacija).^[1] Ovaj enzim katalizuje sledeću hemijsku reakciju

2-amino-3,7-didezoksi-D-treo-hept-6-ulozonat + H₂O + NAD⁺

\rightleftharpoons

3-dehidrohinat + NH₃ + NADH + H⁺

Ovaj enzim, koji je izolovan iz arheje Methanocaldococcus jannaschii, učestvuje u alternativnom putu biosinteze 3-dehidrohinata (DHQ), intermedijera kanoničkog puta biosinteze aromatičnih aminokiselina.

Reference

^ White, R.H. (2004). „L-Aspartate semialdehyde and a 6-deoxy-5-ketohexose 1-phosphate are the precursors to the aromatic amino acids in Methanocaldococcus jannaschii”. Biochemistry. 43: 7618—7627. PMID 15182204.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.

Spoljašnje veze

3-dehydroquinate+synthase+II на US National Library of Medicine Medical Subject Headings (MeSH)

[1] White, R.H. (2004). „L-Aspartate semialdehyde and a 6-deoxy-5-ketohexose 1-phosphate are the precursors to the aromatic amino acids in Methanocaldococcus jannaschii”. Biochemistry. 43: 7618—7627. PMID 15182204.

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