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23S rRNK (guanozin²²⁵¹-2'-O)-metiltransferaza
23S rRNK (guanozin2251-2'-O)-metiltransferaza
Identifikatori
EC broj	2.1.1.185
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
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23S rRNK (guanozin²²⁵¹-2'-O)-metiltransferaza (EC 2.1.1.185, rlmB (gen), yifH (gen)) je enzim sa sistematskim imenom S-adenozil-L-metionin:23S rRNK (guanozin²²⁵¹-2'-O-)-metiltransferaza.^[1]^[2] Ovaj enzim katalizuje sledeću hemijsku reakciju

S-adenozil-L-metionin + guanozin²²⁵¹ u 23S rRNK

\rightleftharpoons

S-adenozil-L-homocistein + 2'-O-metilguanozin²²⁵¹ u 23S rRNK

Enzim katalizuje metilaciju guanozina²²⁵¹. Ta modifikacija je konzervirana u peptidiltransferaznom domenu 23S rRNK.

Reference

^ Lovgren, J.M. & Wikstrom, P.M. (2001). „The rlmB gene is essential for formation of Gm2251 in 23S rRNA but not for ribosome maturation in Escherichia coli”. J. Bacteriol. 183: 6957—6960. PMID 11698387.
^ Michel, G., Sauve, V., Larocque, R., Li, Y., Matte, A. and Cygler, M. (2002). „The structure of the RlmB 23S rRNA methyltransferase reveals a new methyltransferase fold with a unique knot”. Structure. 10: 1303—1315. PMID 12377117.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.

Spoljašnje veze

23S+rRNA+(guanosine2251-2'-O)-methyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Lovgren, J.M. & Wikstrom, P.M. (2001). „The rlmB gene is essential for formation of Gm2251 in 23S rRNA but not for ribosome maturation in Escherichia coli”. J. Bacteriol. 183: 6957—6960. PMID 11698387.

[2] Michel, G., Sauve, V., Larocque, R., Li, Y., Matte, A. and Cygler, M. (2002). „The structure of the RlmB 23S rRNA methyltransferase reveals a new methyltransferase fold with a unique knot”. Structure. 10: 1303—1315. PMID 12377117.

[1]

[2]

23S rRNK (guanozin2251-2'-O)-metiltransferaza

Reference

Literatura

Spoljašnje veze