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1-Dezoksi-D-ksiluloza-5-fosfat sintaza
1-Dezoksi-D-ksiluloza-5-fosfat sintaza
Identifikatori
EC broj	2.2.1.7
CAS broj	202218-79-9
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
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NCBI	proteini

1-Dezoksi-D-ksiluloza-5-fosfat sintaza (EC 2.2.1.7, 1-dezoksi-D-ksiluloza-5-fosfat piruvat-lijaza (karboksilacija), DXP-sintaza) je enzim sa sistematskim imenom piruvat:D-gliceraldehid-3-fosfat acetaldehidtransferaza (dekarboksilacija).^[1]^[2] Ovaj enzim katalizuje sledeću hemijsku reakciju

piruvat + D-gliceraldehid 3-fosfat

\rightleftharpoons

1-dezoksi-D-ksiluloza 5-fosfat + CO₂

Za dejstvo ovog enzima je neophodan tiamin difosfat. Ovaj enzim je deo alternativnog nonmevalonatnog puta za biosintezu terpenoida.

Reference

^ Sprenger, G.A., Schörken, U., Weigert, T., Grolle, S., deGraaf, A.A., Taylor, S.V., Begley, T.P., Bringer-Meyer, S. and Sahm, H. (1997). „Identification of a thiamin-dependent synthase in Escherichia coli required for the formation of the 1-deoxy-D-xylulose 5-phosphate precursor to isoprenoids, thiamin, and pyridoxol”. Proc. Natl. Acad. Sci. USA. 94: 12857—12862. PMID 9371765.
^ Kuzuyama, T., Takagi, M., Takahashi, S. and Seto, H. (2000). „Cloning and characterization of 1-deoxy-D-xylulose 5-phosphate synthase from Streptomyces sp. strain CL190, which uses both the mevalonate and nonmevalonate pathways for isopentenyl diphosphate biosynthesis”. J. Bacteriol. 182: 891—897. PMID 10648511.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.

Spoljašnje veze

1-deoxy-D-xylulose-5-phosphate+synthase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Sprenger, G.A., Schörken, U., Weigert, T., Grolle, S., deGraaf, A.A., Taylor, S.V., Begley, T.P., Bringer-Meyer, S. and Sahm, H. (1997). „Identification of a thiamin-dependent synthase in Escherichia coli required for the formation of the 1-deoxy-D-xylulose 5-phosphate precursor to isoprenoids, thiamin, and pyridoxol”. Proc. Natl. Acad. Sci. USA. 94: 12857—12862. PMID 9371765.

[2] Kuzuyama, T., Takagi, M., Takahashi, S. and Seto, H. (2000). „Cloning and characterization of 1-deoxy-D-xylulose 5-phosphate synthase from Streptomyces sp. strain CL190, which uses both the mevalonate and nonmevalonate pathways for isopentenyl diphosphate biosynthesis”. J. Bacteriol. 182: 891—897. PMID 10648511.

[1]

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