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Acetolaktat sintaza
Acetolaktat sintaza
	Acetolaktat sintaza homotetramer, Bacillus subtilis
Identifikatori
EC broj	2.2.1.6
CAS broj	9027-45-6
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IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
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Acetolaktat sintaza (EC 2.2.1.6, alfa-acetohidroksi kiselinska sintetaza, alfa-acetohidroksikiselinska sintaza, alfa-acetolaktatna sintaza, alfa-acetolaktatna sintetaza, acetohidroksi kiselinska sintetaza, acetohidroksikiselinska sintaza, acetolaktat piruvat-lijaza (karboksilacija), acetomlečna sintetaza) je enzim sa sistematskim imenom piruvat:piruvat acetaldehidtransferaza (dekarboksilacija).^[1]^[2]^[3]^[4] Ovaj enzim katalizuje sledeću hemijsku reakciju

2 piruvat

\rightleftharpoons

2-acetolaktat + CO₂

Za rad ovog enzima je neophodan tiamin difosfat. Prikazana reakcija je deo biosinteze valina. Ovaj enzim takođe može da vrši transfer acetaldehida sa piruvata na 2-oksobutanoata, čime se formira 2-etil-2-hidroksi-3-oksobutanoat, takođe poznat kao 2-aceto-2-hidroksibutanoat.

Reference

^ Bauerle, R.H., Freundlich, M., Størmer, F.C. and Umbarger, H.E. (1964). „Control of isoleucine, valine and leucine biosynthesis. II. Endproduct inhibition by valine of acetohydroxy acid synthetase in Salmonella typhimurium”. Biochim. Biophys. Acta. 92: 142—149. PMID 14243762.
^ Huseby, N.E., Christensen, T.B., Olsen, B.R. and Størmer, F.C. (1971). „The pH 6 acetolactate-forming enzyme from Aerobacter aerogenes. Subunit structure”. Eur. J. Biochem. 20: 209—214. PMID 5560406.
^ Størmer, F.C., Solberg, Y. and Hovig, T. (1969). „The pH 6 acetolactate-forming enzyme from Aerobacter aerogenes. Molecular properties”. Eur. J. Biochem. 10: 251—260. PMID 5823101.
^ Barak, Z., Chipman, D.M. and Gollop, N. (1987). „Physiological implications of the specificity of acetohydroxy acid synthase isozymes of enteric bacteria”. J. Bacteriol. 169: 3750—3756. PMID 3301814.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.

Spoljašnje veze

Acetolactate+synthase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Bauerle, R.H., Freundlich, M., Størmer, F.C. and Umbarger, H.E. (1964). „Control of isoleucine, valine and leucine biosynthesis. II. Endproduct inhibition by valine of acetohydroxy acid synthetase in Salmonella typhimurium”. Biochim. Biophys. Acta. 92: 142—149. PMID 14243762.

[2] Huseby, N.E., Christensen, T.B., Olsen, B.R. and Størmer, F.C. (1971). „The pH 6 acetolactate-forming enzyme from Aerobacter aerogenes. Subunit structure”. Eur. J. Biochem. 20: 209—214. PMID 5560406.

[3] Størmer, F.C., Solberg, Y. and Hovig, T. (1969). „The pH 6 acetolactate-forming enzyme from Aerobacter aerogenes. Molecular properties”. Eur. J. Biochem. 10: 251—260. PMID 5823101.

[4] Barak, Z., Chipman, D.M. and Gollop, N. (1987). „Physiological implications of the specificity of acetohydroxy acid synthase isozymes of enteric bacteria”. J. Bacteriol. 169: 3750—3756. PMID 3301814.

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