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(Fosfataza 2A protein)-leucin-karboksi metiltransferaza
(Fosfataza 2A protein)-leucin-karboksi metiltransferaza
Identifikatori
EC broj	2.1.1.233
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
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PMC	članci
PubMed	članci
NCBI	proteini

(Fosfataza 2A protein)-leucin-karboksi metiltransferaza (EC 2.1.1.233, leucin karboksilna metiltransferaza-1, LCMT1) je enzim sa sistematskim imenom S-adenozil-L-metionin:(fosfataza 2A protein)-leucin O-metiltransferaza.^[1]^[2] Ovaj enzim katalizuje sledeću hemijsku reakciju

S-adenozil-L-metionin + [fosfataza 2A protein]-leucin

\rightleftharpoons

S-adenozil-L-homocistein + [fosfataza 2A protein]-leucin metil estar

Ovaj enzim metiluje C-terminal leucin fosfataze 2A. On je ključni regulator proteinske fosfataze 2A. Metil estar hidrolizuje enzim EC 3.1.1.89 (proteinska fosfataza metilsteraza-1).

Reference

^ De Baere, I., Derua, R., Janssens, V., Van Hoof, C., Waelkens, E., Merlevede, W. and Goris, J. (1999). „Purification of porcine brain protein phosphatase 2A leucine carboxyl methyltransferase and cloning of the human homologue”. Biochemistry. 38: 16539—16547. PMID 10600115.
^ Tsai, M.L., Cronin, N. and Djordjevic, S. (2011). „The structure of human leucine carboxyl methyltransferase 1 that regulates protein phosphatase PP2A”. Acta Crystallogr. D Biol. Crystallogr. 67: 14—24. PMID 21206058.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.

Spoljašnje veze

(phosphatase+2A+protein)-leucine-carboxy+methyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] De Baere, I., Derua, R., Janssens, V., Van Hoof, C., Waelkens, E., Merlevede, W. and Goris, J. (1999). „Purification of porcine brain protein phosphatase 2A leucine carboxyl methyltransferase and cloning of the human homologue”. Biochemistry. 38: 16539—16547. PMID 10600115.

[2] Tsai, M.L., Cronin, N. and Djordjevic, S. (2011). „The structure of human leucine carboxyl methyltransferase 1 that regulates protein phosphatase PP2A”. Acta Crystallogr. D Biol. Crystallogr. 67: 14—24. PMID 21206058.

[1]

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