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Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

(Butirosin acil-nosilac protein)—L-glutamat ligaza
(Butirosin acil-nosilac protein)—L-glutamat ligaza
Identifikatori
EC broj	6.2.1.39
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

(Butirosin acil-nosilac protein)—L-glutamat ligaza (EC 6.2.1.39, (BtrI acil-nosilac protein)—L-glutamat ligaza, BtrJ) je enzim sa sistematskim imenom (BtrI acil-nosilac protein):L-glutamat ligaza (formira ADP).^[1] Ovaj enzim katalizuje sledeću hemijsku reakciju

(1) ATP + L-glutamat + BtrI acil-nosilac protein

\rightleftharpoons

ADP + fosfat + L-glutamil-[BtrI acil-nosilac protein]

(2) ATP + L-glutamat + 4-amino butanoil-[BtrI acil-nosilac protein]

\rightleftharpoons

ADP + fosfat + 4-(gama-L-glutamilamino)butanoil-[BtrI acil-nosilac protein]

Ovaj enzim katalizuje dva koraka u biosintezi bočnog lanca aminoglikozidnih antibiotika iz butirozinske familije.

Reference

^ Li, Y., Llewellyn, N.M., Giri, R., Huang, F. and Spencer, J.B. (2005). „Biosynthesis of the unique amino acid side chain of butirosin: possible protective-group chemistry in an acyl carrier protein-mediated pathway”. Chem. Biol. 12: 665—675. PMID 15975512.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.

Spoljašnje veze

(butirosin+acyl-carrier+protein)-L-glutamate+ligase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Li, Y., Llewellyn, N.M., Giri, R., Huang, F. and Spencer, J.B. (2005). „Biosynthesis of the unique amino acid side chain of butirosin: possible protective-group chemistry in an acyl carrier protein-mediated pathway”. Chem. Biol. 12: 665—675. PMID 15975512.

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