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(-)-Izopiperitenone reduktaza
(-)-Izopiperitenone reduktaza
Identifikatori
EC broj	1.3.1.82
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
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NCBI	proteini

(-)-Izopiperitenone reduktaza (EC 1.3.1.82, (-)-izopiperitenonska reduktaza) je enzim sa sistematskim imenom (+)-cis-izopulegon:NADP⁺ oksidoreduktaza.^[1]^[2] Ovaj enzim katalizuje sledeću hemijsku reakciju

(+)-cis-izopulegon + NADP⁺

\rightleftharpoons

(-)-izopiperitenon + NADPH + H⁺

Ova reakcija teče u reverznom smeru. Enzim učestvuje u putu mentolne biosinteze kod Mentha biljki. (+)-pulegon, (+)-cis-isopulegon i (-)-menton nisu supstrati.

Reference

^ Croteau, R. & Venkatachalam, K.V. (1986). „Metabolism of monoterpenes: demonstration that (+)-cis-isopulegone, not piperitenone, is the key intermediate in the conversion of (-)-isopiperitenone to (+)-pulegone in peppermint (Mentha piperita)”. Arch. Biochem. Biophys. 249: 306—315. PMID 3755881.
^ Ringer, K.L.; cConkey, M.E.; Davis, E.M.; Rushing, G.W.; Croteau, R. (2003). „Monoterpene double-bond reductases of the (-)-menthol biosynthetic pathway: isolation and characterization of cDNAs encoding (-)-isopiperitenone reductase and (+)-pulegone reductase of peppermint”. Arch. Biochem. Biophys. 418: 80—92. PMID 13679086.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.

Spoljašnje veze

(-)-isopiperitenone+reductase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Croteau, R. & Venkatachalam, K.V. (1986). „Metabolism of monoterpenes: demonstration that (+)-cis-isopulegone, not piperitenone, is the key intermediate in the conversion of (-)-isopiperitenone to (+)-pulegone in peppermint (Mentha piperita)”. Arch. Biochem. Biophys. 249: 306—315. PMID 3755881.

[2] Ringer, K.L.; cConkey, M.E.; Davis, E.M.; Rushing, G.W.; Croteau, R. (2003). „Monoterpene double-bond reductases of the (-)-menthol biosynthetic pathway: isolation and characterization of cDNAs encoding (-)-isopiperitenone reductase and (+)-pulegone reductase of peppermint”. Arch. Biochem. Biophys. 418: 80—92. PMID 13679086.

[1]

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