Granulom

Granulom
Mikroskopska slika granuloma (brez nekroze): vzorec tkiva je obarvan s hematoksilinom (modro obarvanje) in eozinom (rožnato obarvanje). Granulom tega bolnika se je nahajal v bezgavki, pri okužbi z Mycobacterium avium.
Specialnostpatologija

Granulóm je majhen, vozličast, slabo omejen skupek mononuklearnih vnetnih celic ali zbir modificiranih makrofagov, ki so podobni epitelijskim celicam, obkrožen z ozkim kolobarjem limfocitov ter redkejšimi celicami velikankami.[1] Nastane kot odziv na kronično vnetno dogajanje. Imunski sistem želi s tvorbo granuloma osamiti tujek, ki povzroča vnetje in ga na drug način ne more izločiti iz telesa.[2] Tujek lahko predstavlja mikrob, kot do bakterije in glive, ali tuja snov v organizmu, keratin ali na primer ostanki kirurških šivov.[3][4][5][6]

Sklici

  1. ↑ https://www.termania.net/slovarji/slovenski-medicinski-slovar/5517348/granulom?query=Granulom&SearchIn=All Slovenski medicinski e-slovar, vpogled: 23. 3. 2022.
  2. ↑ Williams, Olivia; Fatima, Saira (5. april 2020). »Granuloma«. StatPearls. Treasure Island: StatPearls Publishing. PMID 32119473.
  3. ↑ Mukhopadhyay S, Farver CF, Vaszar LT, Dempsey OJ, Popper HH, Mani H, Capelozzi VL, Fukuoka J, Kerr KM, Zeren EH, Iyer VK, Tanaka T, Narde I, Nomikos A, Gumurdulu D, Arava S, Zander DS, Tazelaar HD (Januar 2012). »Causes of pulmonary granulomas: a retrospective study of 500 cases from seven countries«. Journal of Clinical Pathology. 65 (1): 51–57. doi:10.1136/jclinpath-2011-200336. PMID 22011444. S2CID 28504428.
  4. ↑ Woodard BH, Rosenberg SI, Farnham R, Adams DO (1982). »Incidence and nature of primary granulomatous inflammation in surgically removed material«. American Journal of Surgical Pathology. 6 (2): 119–129. doi:10.1097/00000478-198203000-00004. PMID 7102892. S2CID 12907076.
  5. ↑ Hunter DC, Logie JR (1988). »Suture granuloma«. British Journal of Surgery. 75 (11): 1149–1150. doi:10.1002/bjs.1800751140. PMID 3208057. S2CID 12804852.
  6. ↑ Chen KT, Kostich ND, Rosai J (1978). »Peritoneal foreign body granulomas to keratin in uterine adenocanthoma«. Archives of Pathology and Laboratory Medicine. 102 (4): 174–177. PMID 580709.

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