Biloxi (/bɪˈlʌksi/ bih-LUK-see; French: [bilusi]) is the second most populous city in Harrison County and the fourth most populous in the U.S. state of Mississippi, in the United States. The 2020 census recorded the population as 49,449. Biloxi is co–county seat with the larger city Gulfport, in the Gulfport-Biloxi, Mississippi Metropolitan Statistical Area, which is included in the Gulfport-Biloxi-Pascagoula, Mississippi Combined Statistical Area.
The beachfront of Biloxi lies directly on the Mississippi Sound, with barrier islands scattered off the coast and into the Gulf of Mexico.