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The 2000 season was the New England Patriots' 31st in the National Football League (NFL) and their 41st overall. They finished with a 5–11 record and in last place in the division.

Final roster

New England Patriots 2000 final roster

Quarterbacks

Running Backs

Wide Receivers

Tight Ends

Offensive Linemen

Defensive Linemen

Linebackers

Defensive Backs

Special Teams

Reserve Lists

data possibly incomplete

Practice Squad

data possibly incomplete

Notations

Week	Date	Opponent	Result	Record	Stadium
HOF	July 31	vs. San Francisco 49ers	W 20–0	1–0	Fawcett Stadium (Canton, Ohio)
1	August 4	at Detroit Lions	W 13–10	2–0	Pontiac Silverdome
2	August 11	at Washington Redskins	L 20–30	2–1	FedExField
3	August 20	Tampa Bay Buccaneers	L 21–31	2–2	Foxboro Stadium
4	August 24	Carolina Panthers	W 29–21	3–2	Foxboro Stadium

Week	Date	Opponent	Result	Record	Stadium
1	September 3	Tampa Bay Buccaneers	L 16–21	0–1	Foxboro Stadium
2	September 11	at New York Jets	L 19–20	0–2	Giants Stadium
3	September 17	Minnesota Vikings	L 13–21	0–3	Foxboro Stadium
4	September 24	at Miami Dolphins	L 3–10	0–4	Pro Player Stadium
5	October 1	at Denver Broncos	W 28–19	1–4	Mile High Stadium
6	October 8	Indianapolis Colts	W 24–16	2–4	Foxboro Stadium
7	October 15	New York Jets	L 17–34	2–5	Foxboro Stadium
8	October 22	at Indianapolis Colts	L 23–30	2–6	RCA Dome
9	Bye
10	November 5	Buffalo Bills	L 13–16 (OT)	2–7	Foxboro Stadium
11	November 12	at Cleveland Browns	L 11–19	2–8	Cleveland Browns Stadium
12	November 19	Cincinnati Bengals	W 16–13	3–8	Foxboro Stadium
13	November 23	at Detroit Lions	L 9–34	3–9	Pontiac Silverdome
14	December 4	Kansas City Chiefs	W 30–24	4–9	Foxboro Stadium
15	December 10	at Chicago Bears	L 17–24	4–10	Soldier Field
16	December 17	at Buffalo Bills	W 13–10 (OT)	5–10	Ralph Wilson Stadium
17	December 24	Miami Dolphins	L 24–27	5–11	Foxboro Stadium