Tretinoin

Tretinoin
(IUPAC) ime
Retinoinska kiselina
Klinički podaci
Robne marke Avita, Renova, Retin
AHFS/Drugs.com Monografija
MedlinePlus a682437
Identifikatori
CAS broj 302-79-4
ATC kod D10AD01 L01XX14
PubChem[1][2] 444795
DrugBank DB00755
ChemSpider[3] 392618
UNII 5688UTC01R DaY
KEGG[4] D00094 DaY
ChEBI CHEBI:15367 DaY
ChEMBL[5] CHEMBL38 DaY
Hemijski podaci
Formula C20H28O2 
Mol. masa 300,4412 g/mol
SMILES eMolekuli & PubHem
Fizički podaci
Tačka topljenja 180 °C (356 °F)
Farmakokinetički podaci
Vezivanje za proteine plazme > 95%
Poluvreme eliminacije 0,5-2 sata
Farmakoinformacioni podaci
Licenca

US Daily Med:link

Trudnoća ?
Pravni status Samo na recept (S4) (AU) POM (UK) -only (SAD)
Način primene Topikalno, oralno

Tretinoin je kiselinska forma vitamina A. On je poznat kao sve-trans retinoinska kiselina ili ATRA. Tretinoin je lek koji se koristi za tretiranje acne vulgaris i keratosis pilaris. On je dostupan u obliku krema ili gela (Aberela, Airol, Renova, Atralin, Retin-A, Avita, Retacnyl, Refissa, or Stieva-A). On se takođe koristi za treatiranje akutna promijelocitne leukemije (APL), i u prodaji je za tu indikaciju pod imenom Vesanoid. On je dostupan kao generički lek.

Proizvodnja

Jedan od mogućih sintetičkih puteva je:[6]

Reference

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.  edit
  4. Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. 
  5. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.  edit
  6. Lewin, Anita H.; Whaley, M. Glenn; Parker, Steven R.; Carroll, F. Ivy; Moreland, Charles G. (May 1982). „12-Carboxyretinoic acids. Synthesis and structure”. The Journal of Organic Chemistry 47 (10): 1799–1807. DOI:10.1021/jo00349a001. 

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