Protein-lizin 6-oksidaza

Protein-lizin 6-oksidaza
Protein-lizin 6-oksidaza homodimer, Komagataella pastoris
Identifikatori
EC broj 1.4.3.13
CAS broj 99676-44-5
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB RCSB PDB PDBe PDBj PDBsum

Protein-lizin 6-oksidaza (EC 1.4.3.13, lizil oksidaza) je enzim sa sistematskim imenom protein-L-lizin:kiseonik 6-oksidoreduktaza (deaminacija).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju

peptidil-L-lizil-peptid + O2 + H2O peptidil-alizil-peptid + NH3 +H2O2

On takođe deluje na protein 5-hidroksilizin. Ovaj enzim katalizuje final enzimski korak unakrsnog povezivanja kolagena i elastina u biosintezi normalnog odraslog ekstracelularnog matriksa.

Reference

  1. ↑ Harris, E.D., Gonnerman, W.A., Savage, J.E. and O'Dell, B.L. (1974). „Connective tissue amine oxidase. II. Purification and partial characterization of lysyl oxidase from chick aorta”. Biochim. Biophys. Acta 341: 332-344. PMID 4838158. 
  2. ↑ Rayton, J.K. and Harris, E.D. (1979). „Induction of lysyl oxidase with copper. Properties of an in vitro system”. J. Biol. Chem. 254: 621-626. PMID 33171. 
  3. ↑ Stassen, F.L.H. (1976). „Properties of highly purified lysyl oxidase from embryonic chick cartilage”. Biochim. Biophys. Acta 438: 49-60. PMID 7318. 
  4. ↑ Palamakumbura, A.H. and Trackman, P.C. (2002). „A fluorometric assay for detection of lysyl oxidase enzyme activity in biological samples”. Anal. Biochem. 300: 245-251. PMID 11779117. 
  5. ↑ Kagan, H.M., Williams, M.A., Williamson, P.R. and Anderson, J.M. (1984). „Influence of sequence and charge on the specificity of lysyl oxidase toward protein and synthetic peptide substrates”. J. Biol. Chem. 259: 11203-11207. PMID 6147351. 

Literatura

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