O-acetilhomoserin aminokarboksipropiltransferaza

O-acetilhomoserin aminokarboksipropiltransferaza
Identifikatori
EC broj 2.5.1.49
CAS broj 37290-90-7
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB RCSB PDB PDBe PDBj PDBsum

O-acetilhomoserin aminokarboksipropiltransferaza (EC 2.5.1.49, O-acetil-L-homoserin acetat-lijaza (dodaje metantiol), O-acetil-L-homoserin sulfhidrolaza, O-acetilhomoserin (tiol)-lijaza, O-acetilhomoserinsla sulfhidrolaza, metioninska sintaza) je enzim sa sistematskim imenom O-acetil-L-homoserin:metantiol 3-amino-3-karboksipropiltransferaza.[1][2][3][4][5][6][7] Ovaj enzim katalizuje sledeću hemijsku reakciju

O-acetil-L-homoserin + metantiol L-metionin + acetat

Ovaj enzim takođe reaguje sa drugim tiolima i H2S, čime se formira homocistein ili tioetri.

Reference

  1. ↑ Kerr, D. (1971). „O-Acetylhomoserine sulfhydrylase (Neurospora)”. Methods Enzymol. 17B: 446-450. 
  2. ↑ Smith, I.K. and Thompson, J.F. (1969). „Utilization of S-methylcysteine and methylmercaptan by methionineless mutants of Neurospora and the pathway of their conversion to methionine. II. Enzyme studies”. Biochim. Biophys. Acta 184: 130-138. PMID 5791104. 
  3. ↑ Yamagata, S. and Takeshima, K. (1976). „O-Acetylserine and O-acetylhomoserine sulfhydrylase of yeast. Further purification and characterization as a pyridoxal enzyme”. J. Biochem. (Tokyo) 80: 777-785. PMID 795806. 
  4. ↑ Yamagata, S. (1976). „O-Acetylserine and O-acetylhomoserine sulfhydrylase of yeast. Subunit structure”. J. Biochem. (Tokyo) 80: 787-797. PMID 795807. 
  5. ↑ Yamagata, S., Takeshima, K. and Naikai, N. (1974). „Evidence for the identity of O-acetylserine sulfhydrylase with O-acetylhomoserine sulfhydrylase in yeast”. J. Biochem. (Tokyo) 75: 1221-1229. PMID 4609980. 
  6. ↑ Yamagata, S. (1989). „Roles of O-acetyl-L-homoserine sulfhydrylases in micro-organisms”. Biochimie 71: 1125-1143. PMID 2517474. 
  7. ↑ Shimizu, H., Yamagata, S., Masui, R., Inoue, Y., Shibata, T., Yokoyama, S., Kuramitsu, S. and Iwama, T. (2001). „Cloning and overexpression of the oah1 gene encoding O-acetyl-L-homoserine sulfhydrylase of Thermus thermophilus HB8 and characterization of the gene product”. Biochim. Biophys. Acta 1549: 61-72. PMID 11566369. 

Literatura

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