Mitogenom-aktivirana proteinska kinaza kinaza

Mitogenom-aktivirana proteinska kinaza kinaza
Identifikatori
EC broj 2.7.12.2
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB RCSB PDB PDBe PDBj PDBsum

Mitogenom-aktivirane proteinske kinaze kinaze (MAP2K) je enzim koji fosforiliše mitogenom-aktiviranu proteinsku kinazu (MAPK). MAP2K je klasifikovana kao EC 2.7.12.2.

Poznato je sedam gena:

Aktivatori p38 (MKK3 i MKK6), JNK (MKK4 i MKK7), i ERK (MEK1 i MEK2) kinaza definišu nezavisne MAP kinazne puteve prenosa signala.[1][2]

Reference

  1. ↑ Dérijard B, et al. (1995). „Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms”. Science 267 (5198): 682–5. DOI:10.1126/science.7839144. PMID 7839144. 
  2. ↑ Pearson G, Robinson F, Beers Gibson T, Xu BE, Karandikar M, Berman K, Cobb MH (2001). „Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions”. Endocr. Rev. 22 (2): 153–83. DOI:10.1210/er.22.2.153. PMID 11294822. 

Literatura

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