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Mitogenom-aktivirana protein kinaza kinaza kinaza 14
Identifikatori
Simboli	MAP3K14; FTDCR1B; HS; HSNIK; NIK
Vanjski ID	OMIM: 604655 MGI: 1858204 HomoloGene: 2940 GeneCards: MAP3K14 Gene
EC broj	2.7.11.25
Ontologija gena
Molekularna funkcija	• nukleotidno vezivanje; • aktivnost proteinske kinaze; • aktivnost proteinske serin/treonin kinaze; • proteinsko vezivanje; • ATP vezivanje; • aktivnost transferaze;
Biološki proces	• fosforilacija proteinskih aminokiselina;
Pregled RNK izražavanja
	podaci
Ortolozi

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MAP3K14 (Mitogenom-aktivirana protein kinaza kinaza kinaza 14, NF-kapa-B-indukujuća kinaza, NIK), je enzim koji je kod čoveka kodiran MAP3K14 genom.^[1]^[2]

Funkcija

Ovaj gen kodira mitogenom-activiranu kinaza kinaza kinazu 14, koja je serin/treonin-specifična proteinska kinaza. Ova kinaza se vezuje za TRAF2 i stimuliše NF-κB aktivnost. Ona je kritična kinaza alternativnog NF-κB aktivacionog puta. Njena sekvenca je slična sa nekoliko drugih MAPKK kinaza. Ona učestvuje u NF-κB-indukovanoj signalnoj kaskadi koja je zajednička za receptore TNF/NGF) familije i za interleukinski-1 tip-I receptor.^[2]

Interakcije

Za MAP3K14 je pokazano da interaguje sa TRAF2,^[3]^[4] IKK2^[3]^[5] i CHUK.^[6]^[7]^[3]^[8]

Literatura

↑ Malinin NL, Boldin MP, Kovalenko AV, Wallach D (Mar 1997). „MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1”. Nature 385 (6616): 540–4. DOI:10.1038/385540a0. PMID 9020361.
↑ ^2,0 ^2,1 „Entrez Gene: MAP3K14 mitogen-activated protein kinase kinase kinase 14”.
↑ ^3,0 ^3,1 ^3,2 Luftig, M A; Cahir-McFarland E, Mosialos G, Kieff E (May 2001). „Effects of the NIK aly mutation on NF-kappaB activation by the Epstein-Barr virus latent infection membrane protein, lymphotoxin beta receptor, and CD40”. J. Biol. Chem. (United States) 276 (18): 14602–6. DOI:10.1074/jbc.C100103200. ISSN 0021-9258. PMID 11278268.
↑ Malinin, N L; Boldin M P, Kovalenko A V, Wallach D (February 1997). „MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1”. Nature (ENGLAND) 385 (6616): 540–4. DOI:10.1038/385540a0. ISSN 0028-0836. PMID 9020361.
↑ Woronicz, J D; Gao X, Cao Z, Rothe M, Goeddel D V (October 1997). „IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK”. Science (UNITED STATES) 278 (5339): 866–9. DOI:10.1126/science.278.5339.866. ISSN 0036-8075. PMID 9346485.
↑ Régnier, C H; Song H Y, Gao X, Goeddel D V, Cao Z, Rothe M (July 1997). „Identification and characterization of an IkappaB kinase”. Cell (UNITED STATES) 90 (2): 373–83. DOI:10.1016/S0092-8674(00)80344-X. ISSN 0092-8674. PMID 9244310.
↑ Xiao, G; Sun S C (July 2000). „Negative regulation of the nuclear factor kappa B-inducing kinase by a cis-acting domain”. J. Biol. Chem. (UNITED STATES) 275 (28): 21081–5. DOI:10.1074/jbc.M002552200. ISSN 0021-9258. PMID 10887201.
↑ Ninomiya-Tsuji, J; Kishimoto K, Hiyama A, Inoue J, Cao Z, Matsumoto K (March 1999). „The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway”. Nature (ENGLAND) 398 (6724): 252–6. DOI:10.1038/18465. ISSN 0028-0836. PMID 10094049.

Dodatna literatura

Régnier CH, Song HY, Gao X, et al. (1997). „Identification and characterization of an IkappaB kinase.”. Cell 90 (2): 373–83. DOI:10.1016/S0092-8674(00)80344-X. PMID 9244310.
Song HY, Régnier CH, Kirschning CJ, et al. (1997). „Tumor necrosis factor (TNF)-mediated kinase cascades: bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2.”. Proc. Natl. Acad. Sci. U.S.A. 94 (18): 9792–6. DOI:10.1073/pnas.94.18.9792. PMC 23270. PMID 9275204.
Woronicz JD, Gao X, Cao Z, et al. (1997). „IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK.”. Science 278 (5339): 866–9. DOI:10.1126/science.278.5339.866. PMID 9346485.
Ling L, Cao Z, Goeddel DV (1998). „NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176.”. Proc. Natl. Acad. Sci. U.S.A. 95 (7): 3792–7. DOI:10.1073/pnas.95.7.3792. PMC 19916. PMID 9520446.
Lee FS, Peters RT, Dang LC, Maniatis T (1998). „MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta.”. Proc. Natl. Acad. Sci. U.S.A. 95 (16): 9319–24. DOI:10.1073/pnas.95.16.9319. PMC 21336. PMID 9689078.
Lin X, Mu Y, Cunningham ET, et al. (1998). „Molecular determinants of NF-kappaB-inducing kinase action.”. Mol. Cell. Biol. 18 (10): 5899–907. PMC 109176. PMID 9742107.
Cohen L, Henzel WJ, Baeuerle PA (1998). „IKAP is a scaffold protein of the IkappaB kinase complex.”. Nature 395 (6699): 292–6. DOI:10.1038/26254. PMID 9751059.
Aronsson FC, Magnusson P, Andersson B, et al. (1998). „The NIK protein kinase and C17orf1 genes: chromosomal mapping, gene structures and mutational screening in frontotemporal dementia and parkinsonism linked to chromosome 17.”. Hum. Genet. 103 (3): 340–5. DOI:10.1007/s004390050827. PMID 9799091.
Nemoto S, DiDonato JA, Lin A (1998). „Coordinate regulation of IkappaB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-kappaB-inducing kinase.”. Mol. Cell. Biol. 18 (12): 7336–43. PMC 109315. PMID 9819420.
Li Y, Kang J, Friedman J, et al. (1999). „Identification of a cell protein (FIP-3) as a modulator of NF-kappaB activity and as a target of an adenovirus inhibitor of tumor necrosis factor alpha-induced apoptosis.”. Proc. Natl. Acad. Sci. U.S.A. 96 (3): 1042–7. DOI:10.1073/pnas.96.3.1042. PMC 15347. PMID 9927690.
Lallena MJ, Diaz-Meco MT, Bren G, et al. (1999). „Activation of IkappaB kinase beta by protein kinase C isoforms.”. Mol. Cell. Biol. 19 (3): 2180–8. PMC 84010. PMID 10022904.
Lin X, Cunningham ET, Mu Y, et al. (1999). „The proto-oncogene Cot kinase participates in CD3/CD28 induction of NF-kappaB acting through the NF-kappaB-inducing kinase and IkappaB kinases.”. Immunity 10 (2): 271–80. DOI:10.1016/S1074-7613(00)80027-8. PMID 10072079.
Ninomiya-Tsuji J, Kishimoto K, Hiyama A, et al. (1999). „The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway.”. Nature 398 (6724): 252–6. DOI:10.1038/18465. PMID 10094049.
Delhase M, Hayakawa M, Chen Y, Karin M (1999). „Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation.”. Science 284 (5412): 309–13. DOI:10.1126/science.284.5412.309. PMID 10195894.
Hu WH, Johnson H, Shu HB (1999). „Tumor necrosis factor-related apoptosis-inducing ligand receptors signal NF-kappaB and JNK activation and apoptosis through distinct pathways.”. J. Biol. Chem. 274 (43): 30603–10. DOI:10.1074/jbc.274.43.30603. PMID 10521444.
Yamamoto Y, Yin MJ, Gaynor RB (2000). „IkappaB kinase alpha (IKKalpha) regulation of IKKbeta kinase activity.”. Mol. Cell. Biol. 20 (10): 3655–66. DOI:10.1128/MCB.20.10.3655-3666.2000. PMC 85658. PMID 10779355.
Xiao G, Sun SC (2000). „Negative regulation of the nuclear factor kappa B-inducing kinase by a cis-acting domain.”. J. Biol. Chem. 275 (28): 21081–5. DOI:10.1074/jbc.M002552200. PMID 10887201.
Chaudhary PM, Eby MT, Jasmin A, et al. (2000). „Activation of the NF-kappaB pathway by caspase 8 and its homologs.”. Oncogene 19 (39): 4451–60. DOI:10.1038/sj.onc.1203812. PMID 11002417.
Kumar A, Eby MT, Sinha S, et al. (2001). „The ectodermal dysplasia receptor activates the nuclear factor-kappaB, JNK, and cell death pathways and binds to ectodysplasin A.”. J. Biol. Chem. 276 (4): 2668–77. DOI:10.1074/jbc.M008356200. PMID 11035039.

[pmid9020361-1] Malinin NL, Boldin MP, Kovalenko AV, Wallach D (Mar 1997). „MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1”. Nature 385 (6616): 540–4. DOI:10.1038/385540a0. PMID 9020361.

[entrez-2] 2,0 ^2,1 „Entrez Gene: MAP3K14 mitogen-activated protein kinase kinase kinase 14”.

[pmid11278268-3] 3,0 ^3,1 ^3,2 Luftig, M A; Cahir-McFarland E, Mosialos G, Kieff E (May 2001). „Effects of the NIK aly mutation on NF-kappaB activation by the Epstein-Barr virus latent infection membrane protein, lymphotoxin beta receptor, and CD40”. J. Biol. Chem. (United States) 276 (18): 14602–6. DOI:10.1074/jbc.C100103200. ISSN 0021-9258. PMID 11278268.

[autogenerated1-4] Malinin, N L; Boldin M P, Kovalenko A V, Wallach D (February 1997). „MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1”. Nature (ENGLAND) 385 (6616): 540–4. DOI:10.1038/385540a0. ISSN 0028-0836. PMID 9020361.

[pmid9346485-5] Woronicz, J D; Gao X, Cao Z, Rothe M, Goeddel D V (October 1997). „IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK”. Science (UNITED STATES) 278 (5339): 866–9. DOI:10.1126/science.278.5339.866. ISSN 0036-8075. PMID 9346485.

[pmid9244310-6] Régnier, C H; Song H Y, Gao X, Goeddel D V, Cao Z, Rothe M (July 1997). „Identification and characterization of an IkappaB kinase”. Cell (UNITED STATES) 90 (2): 373–83. DOI:10.1016/S0092-8674(00)80344-X. ISSN 0092-8674. PMID 9244310.

[pmid10887201-7] Xiao, G; Sun S C (July 2000). „Negative regulation of the nuclear factor kappa B-inducing kinase by a cis-acting domain”. J. Biol. Chem. (UNITED STATES) 275 (28): 21081–5. DOI:10.1074/jbc.M002552200. ISSN 0021-9258. PMID 10887201.

[pmid10094049-8] Ninomiya-Tsuji, J; Kishimoto K, Hiyama A, Inoue J, Cao Z, Matsumoto K (March 1999). „The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway”. Nature (ENGLAND) 398 (6724): 252–6. DOI:10.1038/18465. ISSN 0028-0836. PMID 10094049.

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