Degradativni enzim

Degradativni enzim je enzim (u širem smislu protein) koji razgrađuje biološke molekule. Neki primeri degradativnih enzima:

Lipaza, razgrađuje lipide,^[1]
Karbohidraza, razgrađuje ugljene hidrate (npr., šećere),^[2]
Proteaza, razgrađuje proteine,^[3]^[4]
Nukleaza, razgrađuje nukleinske kiseline.

Reference

↑ Svendsen A (2000). „Lipase protein engineering”. Biochim Biophys Acta 1543 (2): 223–228. DOI:10.1016/S0167-4838(00)00239-9. PMID 11150608.
↑ „Mechanism of Carbohydrase Action”. Science 125 (3236): 12-15. 1957. DOI:10.1126/science.125.3236.12.
↑ Barrett A.J., Rawlings ND, Woessner JF. The Handbook of Proteolytic Enzymes, 2nd ed. Academic Press, 2003. ISBN 0-12-079610-4.
↑ Hedstrom L. Serine Protease Mechanism and Specificity. Chem Rev 2002;102:4501-4523.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

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