Alfa-N-acetilgalaktozaminidaza

Alfa-N-acetilgalaktozaminidaza
Identifikatori
EC broj 3.2.1.49
CAS broj 9075-63-2
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB RCSB PDB PDBe PDBj PDBsum

Alfa-N-acetilgalaktozaminidaza (EC 3.2.1.49, alfa-acetilgalaktozaminidaza, N-acetil-alfa-D-galaktozaminidaza, N-acetil-alfa-galaktozaminidaza, alfa-NAGAL, alfa-NAGA, alfa-GalNAkaza) je enzim sa sistematskim imenom alfa-N-acetil-D-galaktozaminid N-acetilgalaktozaminohidrolaza.[1][2][3][4][5][6][7] Ovaj enzim katalizuje sledeću hemijsku reakciju

Odvajanje neredukujućih alfa-(1->3)-N-acetilgalaktozaminskih ostataka sa mucinskih glikoproteina ljudske krvne grupe A i AB, Forsman haptena i lakto serije glikolipida krvne grupe A

Ljudski lizozomalni enzim učestvuje u degradaciji epitopa krvnog tipa A.

Reference

  1. ↑ Asfaw, B., Schindler, D., Ledvinova, J., Cerny, B., Smid, F. and Conzelmann, E. (1998). „Degradation of blood group A glycolipid A-6-2 by normal and mutant human skin fibroblasts”. J. Lipid Res. 39: 1768-1780. PMID 9741689. 
  2. ↑ Zhu, A., Monahan, C., Wang, Z.K. and Goldstein, J. (1996). „Expression, purification, and characterization of recombinant α-N-acetylgalactosaminidase produced in the yeast Pichia pastoris”. Protein Expr. Purif. 8: 456-462. PMID 8954893. 
  3. ↑ Clark, N.E. and Garman, S.C. (2009). „The 1.9 Å structure of human α-N-acetylgalactosaminidase: The molecular basis of Schindler and Kanzaki diseases”. J. Mol. Biol. 393: 435-447. PMID 19683538. 
  4. ↑ Hoskins, L.C., Boulding, E.T. and Larson, G. (1997). „Purification and characterization of blood group A-degrading isoforms of α-N-acetylgalactosaminidase from Ruminococcus torques strain IX-70”. J. Biol. Chem. 272: 7932-7939. PMID 9065462. 
  5. ↑ Harun-Or-Rashid, M., Matsuzawa, T., Satoh, Y., Shiraishi, T., Ando, M., Sadik, G. and Uda, Y. (2010). „Purification and characterization of α-N-acetylgalactosaminidases I and II from the starfish Asterina amurensis”. Biosci. Biotechnol. Biochem. 74: 256-261. PMID 20139603. 
  6. ↑ Weignerova, L., Filipi, T., Manglova, D. and Kren, V. (2008). „Induction, purification and characterization of α-N-acetylgalactosaminidase from Aspergillus niger”. Appl. Microbiol. Biotechnol. 79: 769-774. PMID 18443780. 
  7. ↑ Ashida, H., Tamaki, H., Fujimoto, T., Yamamoto, K. and Kumagai, H. (2000). „Molecular cloning of cDNA encoding α-N-acetylgalactosaminidase from 'Acremonium sp. and its expression in yeast”. Arch. Biochem. Biophys. 384: 305-310. PMID 11368317. 

Literatura

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