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AM-938
AM-938
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| (IUPAC) ime
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| (6S,6aR,9R,10aR)-9-(hidroksimetil)-6-(3-hidroksiprop-1-inil)-6-
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| Klinički podaci
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| Identifikatori
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| ATC kod
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?
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| PubChem[1][2]
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10646208
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| ChemSpider[3]
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8821567
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| Hemijski podaci
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| Formula
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C27H40O4
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| Mol. masa
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428,603 g/mol
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| SMILES
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eMolekuli & PubHem
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| InChI |
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InChI=1S/C27H40O4/c1-5-6-7-8-12-26(2,3)20-16-23(30)25-21-15-19(18-29)10-11-22(21)27(4,13-9-14-28)31-24(25)17-20/h16-17,19,21-22,28-30H,5-8,10-12,14-15,18H2,1-4H3/t19-,21-,22-,27+/m1/s1  Y
Key: FFRHKSZKZQWCOY-UOTIDGTBSA-N Y |
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| Farmakoinformacioni podaci
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| Trudnoća
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?
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| Pravni status
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AM-938 je analgetik koji je kanabinoidni agonist. On je derivat HU-210 koji je supstituisan sa 6β-(3-hidroksiprop-1-inil) grupom. To dodaje "južnu" alifatičnu hidroksilnu grupu na molekul, tako da je AM-938 hibridna struktura između klasičnih i neklasičnih kanabinoidnih familija,[4] sa 6-hidroksialkil lancom povećane krutosti usled prisustva trostruke veze. To daje AM-938 povećanu selektivnost.[5][6]
Reference
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
- ↑ Roger Pertwee. Cannabinoids. Handbook of Experimental Pharmacology Volume 168, p 269. Springer. ISBN 3-540-22565-X
- ↑ Tius MA, Hill WA, Zou XL, Busch-Petersen J, Kawakami JK, Fernandez-Garcia MC, Drake DJ, Abadji V, Makriyannis A. Classical/non-classical cannabinoid hybrids; stereochemical requirements for the southern hydroxyalkyl chain. Life Sciences. 1995;56(23-24):2007-12. PMID 7776825
- ↑ Drake DJ, Jensen RS, Busch-Petersen J, Kawakami JK, Concepcion Fernandez-Garcia M, Fan P, Makriyannis A, Tius MA. Classical/nonclassical hybrid cannabinoids: southern aliphatic chain-functionalized C-6beta methyl, ethyl, and propyl analogues. Journal of Medicinal Chemistry. 1998 Sep 10;41(19):3596-608. PMID 9733485
Povezano
Šablon:Kanabinoidi
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