Pramipexol

Pramipexol
Identificare
Număr CAS104632-26-0[1]  Modificați la Wikidata
PubChem119570[2]  Modificați la Wikidata
DrugBankDB00413  Modificați la Wikidata
ChemSpider106770[3]  Modificați la Wikidata
UNII83619PEU5T[4]  Modificați la Wikidata
KEGGD00559[5]  Modificați la Wikidata
ChEMBLCHEMBL301265[6]  Modificați la Wikidata
Cod ATCN04BC05[7]  Modificați la Wikidata
SMILES
CCCNC1CCC2=C(C1)SC(=N2)N[2]  Modificați la Wikidata
InChI
InChI=InChI=1S/C10H17N3S/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8/h7,12H,2-6H2,1H3,(H2,11,13)/t7-/m0/s1[2]  Modificați la Wikidata
Date chimice
FormulăC₁₀H₁₇N₃S[2]  Modificați la Wikidata
Masă molară211,114 u.a.m.[2]  Modificați la Wikidata
Modifică date / text Consultați documentația formatului

Pramipexolul este un medicament antiparkinsonian derivat de tiazol ce este utilizat în tratamentul bolii Parkinson.[8][9] Calea de administrare disponibilă este cea orală.[8] Este un agonist al receptorilor dopamiergici de tipul D2, D3 și D4.[9][10][11]

Molecula a fost aprobată pentru uz medical în Statele Unite ale Americii în anul 1997.[8]

Utilizări medicale

Pramipexolul este utilizat în tratamentul bolii Parkinson, în forma idiopatică, ca monoterapie (fără levodopa) sau în asociere cu levodopa.[8][9][12]

Note

  1. ^ a b CAS Common Chemistry, accesat în  
  2. ^ a b c d e f g h i j k l m n „Pramipexol”, pramipexole (în engleză), PubChem, accesat în  
  3. ^ a b Pramipexole (în engleză), ChemSpider, accesat în  
  4. ^ a b pramipexole (în engleză), Global Substance Registration System, accesat în  
  5. ^ a b pramipexole (în engleză), ChEBI, accesat în  
  6. ^ a b PRAMIPEXOLE (în engleză), ChEMBL, accesat în  
  7. ^ a b Pramipexole (în engleză), DrugBank,  
  8. ^ a b c d „Pramipexole”. The American Society of Health-System Pharmacists. Accesat în . 
  9. ^ a b c „Pramipexole”. DrugBank - Canadian Institutes of Health Research. Accesat în . 
  10. ^ Kvernmo T, Härtter S, Burger E (august 2006). „A review of the receptor-binding and pharmacokinetic properties of dopamine agonists”. Clinical Therapeutics. 28 (8): 1065–78. doi:10.1016/j.clinthera.2006.08.004. PMID 16982285. 
  11. ^ Newman-Tancredi A, Cussac D, Audinot V, et al. (noiembrie 2002). „Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. II. Agonist and antagonist properties at subtypes of dopamine D(2)-like receptor and alpha(1)/alpha(2)-adrenoceptor”. The Journal of Pharmacology and Experimental Therapeutics. 303 (2): 805–14. doi:10.1124/jpet.102.039875. PMID 12388667. 
  12. ^ „Rezumatul caracteristicilor produsului - Calmolan 0,26 mg comprimate cu eliberare prelungită” (PDF). Agenția Națională a Medicamentului și a Dispozitivelor Medicale din România. Arhivat din original (PDF) la . Accesat în . 

Vezi și

 Acest articol legat de un medicament este un ciot. Puteți ajuta Wikipedia prin completarea lui.


v • d • m
Antiparkinsoniene (ATC N04)
Dopaminergice
Levodopa#  • Melevodopa
Agoniști dopaminergici
Inhibitori de MAO-B
Inhibitori de COMT
Inhibitori de DDCP
Anticolinergice
Altele

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