Clormetină

Clormetină
Identificare
Număr CAS51-75-2[1][2][3]  Modificați la Wikidata
PubChem4033[4]  Modificați la Wikidata
DrugBankDB00888  Modificați la Wikidata
ChemSpider3893[5]  Modificați la Wikidata
UNII50D9XSG0VR[2]  Modificați la Wikidata
KEGGD07671[6]  Modificați la Wikidata
ChEMBLCHEMBL427[7]  Modificați la Wikidata
Cod ATCL01AA05[8]  Modificați la Wikidata
SMILES
CN(CCCl)CCCl[4]  Modificați la Wikidata
InChI
InChI=InChI=1S/C5H11Cl2N/c1-8(4-2-6)5-3-7/h2-5H2,1H3[4]  Modificați la Wikidata
Date chimice
FormulăC₅H₁₁Cl₂N[4]  Modificați la Wikidata
Masă molară155,026855 u.a.m.[9]  Modificați la Wikidata
Date fizice
Punct de topire−60 °C[10]  Modificați la Wikidata
Punct de fierbere75 °C[10]  Modificați la Wikidata
Modifică date / text Consultați documentația formatului

Clormetina (denumită și mecloretamină) este un medicament chimioterapic din clasa agenților alchilanți, fiind un derivat de azot-iperită (muștar de azot).[11][12][13] Este utilizat intravenos în tratamentul limfoamelor Hodgkin[11] și topic în tratamentul limfomului cutanat cu celule T (de tip micozis fungoid).[14][15][16]

Note

  1. ^ a b ML7.b.2.c.2 (PDF), List of Dual-Use Goods and Technologies and Munitions List 
  2. ^ a b c d mechlorethamine (în engleză), Global Substance Registration System, accesat în  
  3. ^ a b CAS Common Chemistry, accesat în  
  4. ^ a b c d e f g h i j k l „Clormetină”, mechlorethamine (în engleză), PubChem, accesat în  
  5. ^ a b chlormethine (în engleză), ChemSpider, accesat în  
  6. ^ a b mechlorethamine (în engleză), ChEBI, accesat în  
  7. ^ a b MECHLORETHAMINE (în engleză), ChEMBL, accesat în  
  8. ^ a b Mechlorethamine (în engleză), DrugBank,  
  9. ^ a b „Clormetină”, mechlorethamine (în engleză), PubChem, accesat în  
  10. ^ a b c d http://www.cdc.gov/niosh/ershdb/emergencyresponsecard_29750011.html  Lipsește sau este vid: |title= (ajutor)
  11. ^ a b „Mechlorethamine (Systemic)”. The American Society of Health-System Pharmacists. Arhivat din original la . Accesat în . 
  12. ^ „Mechlorethamine”. DrugBank - Canadian Institutes of Health Research. Accesat în . 
  13. ^ Rappeneau S, Baeza-Squiban A, Jeulin C, Marano F (martie 2000). „Protection from cytotoxic effects induced by the nitrogen mustard mechlorethamine on human bronchial epithelial cells in vitro”. Toxicol. Sci. 54 (1): 212–21. doi:10.1093/toxsci/54.1.212. PMID 10746948. 
  14. ^ „Mechlorethamine (Topical)”. The American Society of Health-System Pharmacists. Accesat în . 
  15. ^ „Rezumatul caracteristicilor produsului - Ledaga 160 micrograme/g gel” (PDF). Agenția Europeană a Medicamentului. Accesat în . 
  16. ^ Lindahl LM, Fenger-Gron M, Iversen L. Topical nitrogen mustard therapy in patients with mycosis fungoides or parapsoriasis. J Eur Acad Dermatol Venereol. 2013 Feb;27(2):163-8.

Vezi și

 Acest articol legat de un medicament este un ciot. Puteți ajuta Wikipedia prin completarea lui.


v • d • m
Agenți chimioterapici intracelulari și antineoplazice (cod ATC L01)
Inhibitori ai
replicării ADN
Azot-iperite
Bendamustină#  • Clorambucil#  • Clormetină  • Melfalan  • Uramustină
Oxazafosforine: Ciclofosfamidă#  • Ifosfamidă#  • Trofosfamidă (+ Mesna#, adjuvant)
Nitrozouree
Sulfonați de alchil
Compuși ai platinei
Carboplatină#  • Cisplatină#  • Dicicloplatină  • Nedaplatină  • Oxaliplatină#  • Satraplatină
Altele
Aminopterină  • Metotrexat# (+ Folinat#, adjuvant)  • Pemetrexed  • Raltitrexed
I
Derivați de camptotecină: Irinotecan#  • Topotecan  • Rubitecan‡
II
Derivați de epipodofilotoxină: Etopozid#  • Tenipozid
Inhibitori ai
fusului mitotic
Blocanți ai asamblării microtubulilor
Blocanți ai dezasamblării microtubulilor
Taxani: Cabazitaxel  • Docetaxel#  • Paclitaxel#; epotilone: Ixabepilonă
Inhibitori enzimatici
Alte clase

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