Viqualina

Viqualina
Alerta sobre risco à saúde
Nome IUPAC 4-[3-[(3R,4R)-3-Ethenylpiperidin-4-yl]propyl]-6-methoxyquinoline
Outros nomes PK-5078 (código de desenvolvimento)
Identificadores
Número CAS 72714-74-0
PubChem 3050111
SMILES
Propriedades
Fórmula química C20H26N2O
Massa molar 310.43 g mol-1
Página de dados suplementares
Estrutura e propriedades n, εr, etc.
Dados termodinâmicos Phase behaviour
Solid, liquid, gas
Dados espectrais UV, IV, RMN, EM
Exceto onde denotado, os dados referem-se a
materiais sob condições normais de temperatura e pressão
Referências e avisos gerais sobre esta caixa.
Alerta sobre risco à saúde.

Viqualina (DCI); código de desenvolvimento: PK-5078) é um antidepressivo e ansiolítico que nunca foi comercializado.[1][2][3] Atua como um inibidor seletivo da recaptação de serotonina e agente de liberação de serotonina potente.[3][4] Além disso, a viqualina desloca o diazepam do receptor GABAA, produzindo efeitos semelhantes ao dos benzodiazepínicos, de modo que também é um modulador alostérico positivo (agonista alostérico) do sítio benzodiazepínico no receptor GABAA.[3][5] A droga é objeto de pesquisa principalmente como um tratamento em potencial para o alcoolismo.[6][7]

Ver também

Referências

  1. ↑ The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. [S.l.]: Springer. 14 de novembro de 2014. pp. 1–. ISBN 978-1-4757-2085-3 
  2. ↑ Faravelli C, Albanesi G, Sessarego A (1988). «Viqualine in resistant depression: a double-blind, placebo-controlled trial». Neuropsychobiology. 20 (2): 78–81. PMID 3075725. doi:10.1159/000118477 
  3. ↑ a b c Pharmacotherapy for Depression and Treatment-resistant Depression. [S.l.]: World Scientific. 2010. pp. 304–. ISBN 978-981-4287-59-3 
  4. ↑ Le Fur G, Imbault F, Mitrani N, Marquis F, Renault C, Dubroeucq MC, et al. (fevereiro de 1984). «The 5-hydroxytryptamine-releasing properties of two epimer quinoline derivatives». Neuropharmacology. 23 (2A): 169–173. PMID 6717757. doi:10.1016/S0028-3908(84)80010-6 
  5. ↑ Faravelli C, Albanesi G, Sessarego A (1988). «Viqualine in resistant depression: a double-blind, placebo-controlled trial». Neuropsychobiology. 20 (2): 78–81. PMID 3075725. doi:10.1159/000118477 
  6. ↑ Naranjo CA, Sellers EM (1989). «Serotonin uptake inhibitors attenuate ethanol intake in problem drinkers». Recent Developments in Alcoholism. 7: 255–266. ISBN 978-1-4899-1680-8. PMID 2522667. doi:10.1007/978-1-4899-1678-5_13 
  7. ↑ Naranjo CA, Sullivan JT, Kadlec KE, Woodley-Remus DV, Kennedy G, Sellers EM (setembro de 1989). «Differential effects of viqualine on alcohol intake and other consummatory behaviors». Clinical Pharmacology and Therapeutics. 46 (3): 301–309. PMID 2673621. doi:10.1038/clpt.1989.142 
Ícone de esboço Este artigo sobre fármacos é um esboço. Você pode ajudar a Wikipédia expandindo-o.

Read other articles:

Keuskupan Manzini

Keuskupan ManziniDioecesis ManziniensisLokasiNegara SwazilandMetropolitJohannesburg (di Afrika Selatan)StatistikLuas17.364 km2 (6.704 sq mi)Populasi- Total- Katolik(per 2015)1.119.15556,000 (5.0%)InformasiRitusRitus LatinKatedralKatedral Bunda Maria Diangkat ke Surga, ManziniKepemimpinan kiniPausFransiskusUskupJosé Luís Gerardo Ponce de León, I.M.C. Keuskupan Manzini (Latin: Dioecesis Manziniensiscode: la is deprecated ) adalah sebuah keuskupan Gerej...

 

Khoirul Umri

Artikel ini perlu diwikifikasi agar memenuhi standar kualitas Wikipedia. Anda dapat memberikan bantuan berupa penambahan pranala dalam, atau dengan merapikan tata letak dari artikel ini. Untuk keterangan lebih lanjut, klik [tampil] di bagian kanan. Mengganti markah HTML dengan markah wiki bila dimungkinkan. Tambahkan pranala wiki. Bila dirasa perlu, buatlah pautan ke artikel wiki lainnya dengan cara menambahkan [[ dan ]] pada kata yang bersangkutan (lihat WP:LINK untuk keterangan lebih lanjut...

 

Roland (Lully)

Opera by Jean-Baptiste Lully Roland (title page) Roland is an opera with music by Jean-Baptiste Lully and a libretto by Philippe Quinault. It was first performed on January 8, 1685, at the Palace of Versailles by the Académie Royale de Musique (Paris Opera) and later, beginning on March 8, 1685, at the company's public theatre in Paris, the Théâtre du Palais-Royal. The story is derived from Ariosto's epic poem Orlando Furioso. The opera takes the form of a tragédie en musique with an alle...

St. Francois Mountains

Mountain range in Missouri, United States Saint Francois MountainsA view towards the St. Francois range from Knob Lick Mountain, a granite and rhyolite knob on the edge of the rangeHighest pointPeakTaum Sauk MountainElevation1,772 ft (540 m)Coordinates37°34′13″N 90°43′40″W / 37.57028°N 90.72778°W / 37.57028; -90.72778GeographyA relief map of Missouri showing the St. Francois Mountain region (red) CountryUnited StatesStateMissouriGeologyAge of...

 

Nicola Porta

Disambiguazione – Se stai cercando altri significati, vedi Nicola Porta (disambigua). Nicola di Castro Arquatopatriarca della Chiesa cattolica  Incarichi ricoperti Vescovo di Spoleto (prima del 1228-1234) Patriarca latino di Costantinopoli (1234-1251)  Natoa Castell'Arquato Elevato patriarca1234 Deceduto1251 a Mirano   Manuale Nicola Porta, noto anche come Nicola di Castro Arquato[1] o Nicolò di Piacenza[2] (Castell'Arquato, ... – Mirano, 1251) è stato un...

 

وارين هاستينغز

هذه المقالة تحتاج للمزيد من الوصلات للمقالات الأخرى للمساعدة في ترابط مقالات الموسوعة. فضلًا ساعد في تحسين هذه المقالة بإضافة وصلات إلى المقالات المتعلقة بها الموجودة في النص الحالي. (مارس 2018) وارين هاستينغز (بالإنجليزية: Warren Hastings)‏    معلومات شخصية الميلاد 6 ديسمبر 1732...

568th Air Defense Group

568th Air Defense Group5th Fighter-Interceptor Squadron, F-86D Sabre at McGuire AFB[a]Active1945–1946; 1952–1954Country United StatesBranch United States Air ForceTypeFighter interceptorRoleAir defenseMilitary unit The 568th Air Defense Group is a disbanded United States Air Force organization. Its last assignment was with Air Defense Command (ADC)'s 4709th Air Defense Wing at McGuire Air Force Base, New Jersey, where it was inactivated in 1954. The group was originally...

 

A Separation

2011 Iranian filmA SeparationTheatrical release posterDirected byAsghar FarhadiWritten byAsghar FarhadiProduced byAsghar FarhadiStarring Leila Hatami Peyman Moaadi Shahab Hosseini Kimiya Hosseini Babak Karimi Sareh Bayat Sarina Farhadi Merila Zarei CinematographyMahmoud KalariEdited byHayedeh SafiyariMusic bySattar OrakiDistributed byFilmiranRelease dates 15 February 2011 (2011-02-15) (Berlin) 16 March 2011 (2011-03-16) (Iran) Running time123 minutes[...

 

Symposium

Part of a banquet in Greek and Etruscan art This article is about the social custom in ancient Greece. For other uses, see Symposium (disambiguation). A symposium scene on a fresco in the Tomb of the Diver from the Greek colony of Paestum, in Italy, 480–470 BC A female aulos-player entertains men at a symposium on this Attic red-figure bell-krater, c. 420 BC. In Ancient Greece, the symposium (Greek: συμπόσιον, sympósion or symposio, from συμπίνειν, sympínein, to dr...

178th Wing

This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.Find sources: 178th Wing – news · newspapers · books · scholar · JSTOR (May 2016) (Learn how and when to remove this message) 178th WingGeneral Atomics MQ-1 Predator UAV 05-3141 taking offActive1962-presentCountry United StatesAllegiance OhioBranch  Air Nation...

 

Mannele

Si ce bandeau n'est plus pertinent, retirez-le. Cliquez ici pour en savoir plus. Cet article ne cite pas suffisamment ses sources (novembre 2012). Si vous disposez d'ouvrages ou d'articles de référence ou si vous connaissez des sites web de qualité traitant du thème abordé ici, merci de compléter l'article en donnant les références utiles à sa vérifiabilité et en les liant à la section « Notes et références ». En pratique : Quelles sources sont attendues ? ...

 

Unusual (song)

For other songs with the same title, see Unusual (disambiguation). 2011 single by Trey Songz featuring DrakeUnusualSingle by Trey Songz featuring Drakefrom the album Passion, Pain & Pleasure ReleasedMay 17, 2011 (2011-05-17) (U.S. urban radio)[1]Recorded2010GenreR&BLength3:32Label Songbook Atlantic Songwriter(s) Tremaine Neverson Aubrey Graham Andrew Pop Wansel Warren Oak Felder Dexter Wansel Ezekiel Lewis John Maultsby Melvin Moore Floyd Bentley Producer(s) Pop...

Gempa bumi tektonik

Gempa bumi tektonik adalah jenis gempa Bumi yang disebabkan oleh pergeseran tiba-tiba pada sebuah patahan tektonik. Lempeng tektonik selalu bergerak secara perlahan, tetapi mereka terjebak pada masing-masing tepian mereka karena hambatan gesekan. Ketika tekanan di bagian tepi melampaui hambatan gesekan, terjadilah gempa bumi yang melepaskan energi dalam bentuk gelombang yang menjalar melalui kerak bumi dan menyebabkan guncangan yang kita rasakan.[1] Penyebab Tiga tipe patahan:A. Strik...

 

Філософія

Частина серії проФілософіяLeft to right: Plato, Kant, Nietzsche, Buddha, Confucius, AverroesПлатонКантНіцшеБуддаКонфуційАверроес Філософи Епістемологи Естетики Етики Логіки Метафізики Соціально-політичні філософи Традиції Аналітична Арістотелівська Африканська Близькосхідна іранська Буддій�...

 

中華民國國軍中的中共間諜列表

 本表是動態列表，或許永遠不會完結。歡迎您參考可靠來源來查漏補缺。 潛伏於中華民國國軍中的中共間諜列表收錄根據公開資料來源，曾潛伏於中華民國國軍、被中國共產黨聲稱或承認，或者遭中華民國政府調查審判，為中華人民共和國和中國人民解放軍進行間諜行為的人物。以下列表以現今可查知時間為準，正確的間諜活動或洩漏機密時間可能早於或晚於以下所歸�...

منتخب أرمينيا لكرة السلة للسيدات

يفتقر محتوى هذه المقالة إلى الاستشهاد بمصادر. فضلاً، ساهم في تطوير هذه المقالة من خلال إضافة مصادر موثوق بها. أي معلومات غير موثقة يمكن التشكيك بها وإزالتها. (يوليو 2019) هذه المقالة تحتاج للمزيد من الوصلات للمقالات الأخرى للمساعدة في ترابط مقالات الموسوعة. فضلًا ساعد في تحسي...

 

Hampshire County, Massachusetts

County in Massachusetts, United States County in MassachusettsHampshire CountyCountyOld Hampshire County Courthouse SealLocation within the U.S. state of MassachusettsMassachusetts's location within the U.S.Coordinates: 42°20′N 72°40′W / 42.34°N 72.66°W / 42.34; -72.66Country United StatesState MassachusettsFounded1662Named forHampshire, EnglandSeatNorthamptonLargest townAmherstArea • Total545 sq mi (1,410 km2) • ...

 

Stéphane Tritz

French footballer Stéphane Tritz Personal informationDate of birth (1987-02-25) 25 February 1987 (age 37)Place of birth Strasbourg, FranceHeight 1.76 m (5 ft 9 in)Position(s) Right back[1]Team informationCurrent team Wormatia WormsNumber 16Youth career2003–2005 StrasbourgSenior career*Years Team Apps (Gls)2005–2008 Strasbourg B 70 (2)2009 Colmar 10 (0)2009–2010 Rodez 37 (0)2010–2014 Tours 59 (0)2014 Oțelul Galați 10 (0)2014–2015 Brest B 12 (0)2014–20...

Karim Coulibaly

Questa voce sugli argomenti calciatori senegalesi e calciatori francesi è solo un abbozzo. Contribuisci a migliorarla secondo le convenzioni di Wikipedia. Segui i suggerimenti dei progetti di riferimento 1, 2. Karim CoulibalyNazionalità Senegal Francia Altezza184 cm Peso80 kg Calcio RuoloAttaccante Squadra Épinal CarrieraGiovanili 1993-2008 US Villejuif2008-2011 Nancy Squadre di club1 2011-2017 Nancy 245 (10)2012-2017 Nancy77 (10)2017-2020 Willem II...

 

Hrvatski Nogometni Klub Hajduk Split

H.N.K. Hajduk SplitCalcio Hajduci, Bili (I Bianchi), Splitski Bili (I Bianchi di Spalato), Majstori s mora Segni distintiviUniformi di gara Casa Trasferta Terza divisa Colori sociali Bianco InnoZbog jedne ljubaviTorcida Split Dati societariCittàSpalato Nazione Croazia ConfederazioneUEFA Federazione HNS CampionatoHNL Fondazione1911 Presidente Ivan Bilić Allenatore Gennaro Gattuso StadioPoljud(33987 posti) Sito webwww.hajduk.hr PalmarèsTitoli nazionali9 campionati jugoslavi6 campionati ...