Melarsoprol



Melarsoprol Aviso médico
Nome IUPAC (sistemática)
(2-(4-(4,6-diamino-1,3,5-triazin-2-ylamino)phenyl)- 1,3,2-dithiarsolan-4-yl)methanol
Identificadores
CAS	494-79-1
ATC	P01CD01 QP51AD04
PubChem	10311
Informação química
Fórmula molecular	C₁₂H₁₅N₆O S₂
Massa molar	398.341 g/mol
Sinónimos	“Mel B”, “Melarsen Oxide-BAL”
Farmacocinética
Biodisponibilidade	?
Metabolismo	?
Meia-vida	35 h
Excreção	Renal
Considerações terapêuticas
Administração	Intravenosa
DL₅₀	?

Melarsoprol (DCI) é um medicamento utilizado no tratamento da doença do sono, causada pelo Trypanosoma brucei.^[1] Também é vendida pelos nomes comerciais "Mel B" e "Melarsen Oxide-BAL".

Melarsoprol também é usado no tratamento da doença de Chagas^[^{carece de fontes?]}, causada pelo Trypanosoma cruzi.

Efeitos colaterais

Sendo um composto orgânico tóxico de arsênico, o tratamento com melarsoprol é extremamente perigoso e só é administrado por injeção sob a supervisão de um médico.

É sabido que causa uma série de efeitos colaterais, incluindo convulsões, febre, perda de consciência, feridas na pele, sangue nas fezes, náuseas e vômito. Seu uso é fatal, por si só, em aproximadamente 8% dos casos.^[2]

Alternativas

Eflornitina é um tratamento mais moderno e bem menos perigoso para a doença do sono.^[3] Entretanto, é uma droga cara, pouco disponível no mercado e a maior parte do seu suprimento vem de doações de seu fabricante. De qualquer forma, eflornitina somente é efetiva para a forma da doença encontrada na África Ocidental; não produz efeito algum contra a doença do sono da África Oriental.

Notas

Este artigo foi inicialmente traduzido, total ou parcialmente, do artigo da Wikipédia em inglês cujo título é «Melarsoprol», especificamente desta versão.

Referências

↑ Bisser S, N'Siesi FX, Lejon V; et al. (2007). «Equivalence trial of melarsoprol and nifurtimox monotherapy and combination therapy for the treatment of second-stage Trypanosoma brucei gambiense sleeping sickness». J. Infect. Dis. 195 (3): 322–9. PMID 17205469. doi:10.1086/510534
↑ Bulletin of the World Health Organization vol.84 no.10 Genebra Oct. 2006 - Melarsoprol versus eflornithine for treating late-stage Gambian trypanosomiasis in the Republic of the Congo
↑ Chappuis F, Udayraj N, Stietenroth K, Meussen A, Bovier PA (2005). «Eflornithine is safer than melarsoprol for the treatment of second-stage Trypanosoma brucei gambiense human African trypanosomiasis». Clin. Infect. Dis. 41 (5): 748–51. PMID 16080099. doi:10.1086/432576

Este artigo sobre Medicamento é um esboço. Você pode ajudar a Wikipédia expandindo-o.

Identificadores	ATC: P01CD01 CAS: 494-79-1 ChEBI: 6729 ChEMBL: CHEMBL166 ChemSpider: 9889 DrugBank: DB12864 DTXSID: DTXSID90862033 ECHA: 100.007.086 KEGG: D00832 KNApSAcK: C00061937 MeSH: D008549 MeSH: D02.129.500 PubChem: 10311 UNII: ZF3786Q2E8

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