LATS1
A grande supressora de tumor quinase 1 (LATS1) é uma enzima que em humanos é codificada pelo gene LATS1.[2][3][4]
Ele foi associado à via de sinalização Hippo.[5][6][7]
Interações
O LATS1 demonstrou interagir com Zyxin[8] e Cdk1.[2]
Referências
- ↑ «Human PubMed Reference:»
- ↑ a b Tao W, Zhang S, Turenchalk GS, Stewart RA, St John MA, Chen W, Xu T (fevereiro de 1999). «Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity». Nat Genet. 21 (2): 177–81. PMID 9988268. doi:10.1038/5960
- ↑ Iida S, Hirota T, Morisaki T, Marumoto T, Hara T, Kuninaka S, Honda S, Kosai K, Kawasuji M, Pallas DC, Saya H (julho de 2004). «Tumor suppressor WARTS ensures genomic integrity by regulating both mitotic progression and G1 tetraploidy checkpoint function». Oncogene. 23 (31): 5266–74. PMID 15122335. doi:10.1038/sj.onc.1207623
- ↑ «Entrez Gene: LATS1 LATS, large tumor suppressor, homolog 1 (Drosophila)»
- ↑ Saucedo LJ, Edgar BA (agosto de 2007). «Filling out the Hippo pathway». Nature Reviews. Molecular Cell Biology. 8 (8): 613–21. PMID 17622252. doi:10.1038/nrm2221
- ↑ Zhao B, Tumaneng K, Guan KL (agosto de 2011). «The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal». Nature Cell Biology. 13 (8): 877–83. PMC 3987945
. PMID 21808241. doi:10.1038/ncb2303
- ↑ Hao Y, Chun A, Cheung K, Rashidi B, Yang X (fevereiro de 2008). «Tumor suppressor LATS1 is a negative regulator of oncogene YAP». J. Biol. Chem. 283 (9): 5496–509. PMID 18158288. doi:10.1074/jbc.M709037200
- ↑ Hirota, T; Morisaki T; Nishiyama Y; Marumoto T; Tada K; Hara T; Masuko N; Inagaki M; Hatakeyama K; Saya H (maio de 2000). «Zyxin, a regulator of actin filament assembly, targets the mitotic apparatus by interacting with h-warts/LATS1 tumor suppressor». J. Cell Biol. 149 (5): 1073–86. ISSN 0021-9525. PMC 2174824. PMID 10831611. doi:10.1083/jcb.149.5.1073
Leitura adicional
- Xu T, Wang W, Zhang S, et al. (1995). «Identifying tumor suppressors in genetic mosaics: the Drosophila lats gene encodes a putative protein kinase.». Development. 121 (4): 1053–63. PMID 7743921
- St John MA, Tao W, Fei X, et al. (1999). «Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction.». Nat. Genet. 21 (2): 182–6. PMID 9988269. doi:10.1038/5965
- Nishiyama Y, Hirota T, Morisaki T, et al. (1999). «A human homolog of Drosophila warts tumor suppressor, h-warts, localized to mitotic apparatus and specifically phosphorylated during mitosis.». FEBS Lett. 459 (2): 159–65. PMID 10518011. doi:10.1016/S0014-5793(99)01224-7
- Hirota T, Morisaki T, Nishiyama Y, et al. (2000). «Zyxin, a regulator of actin filament assembly, targets the mitotic apparatus by interacting with h-warts/LATS1 tumor suppressor.». J. Cell Biol. 149 (5): 1073–86. PMC 2174824. PMID 10831611. doi:10.1083/jcb.149.5.1073
- Morisaki T, Hirota T, Iida S, et al. (2002). «WARTS tumor suppressor is phosphorylated by Cdc2/cyclin B at spindle poles during mitosis.». FEBS Lett. 529 (2–3): 319–24. PMID 12372621. doi:10.1016/S0014-5793(02)03360-4
- Hisaoka M, Tanaka A, Hashimoto H (2002). «Molecular alterations of h-warts/LATS1 tumor suppressor in human soft tissue sarcoma». Lab. Invest. 82 (10): 1427–35. PMID 12379777. doi:10.1097/01.lab.0000032381.68634.ca
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). «Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences». Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899
- Kamikubo Y, Takaori-Kondo A, Uchiyama T, Hori T (2003). «Inhibition of cell growth by conditional expression of kpm, a human homologue of Drosophila warts/lats tumor suppressor». J. Biol. Chem. 278 (20): 17609–14. PMID 12624101. doi:10.1074/jbc.M211974200
- Brill LM, Salomon AR, Ficarro SB, et al. (2004). «Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry». Anal. Chem. 76 (10): 2763–72. PMID 15144186. doi:10.1021/ac035352d
- Yang X, Yu K, Hao Y, et al. (2004). «LATS1 tumour suppressor affects cytokinesis by inhibiting LIMK1». Nat. Cell Biol. 6 (7): 609–17. PMID 15220930. doi:10.1038/ncb1140
- Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). «Large-scale characterization of HeLa cell nuclear phosphoproteins». Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. PMC 514446. PMID 15302935. doi:10.1073/pnas.0404720101
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). «The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)». Genome Res. 14 (10B): 2121–7. PMC 528928. PMID 15489334. doi:10.1101/gr.2596504
- Chan EH, Nousiainen M, Chalamalasetty RB, et al. (2005). «The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1». Oncogene. 24 (12): 2076–86. PMID 15688006. doi:10.1038/sj.onc.1208445
- Takahashi Y, Miyoshi Y, Takahata C, et al. (2005). «Down-regulation of LATS1 and LATS2 mRNA expression by promoter hypermethylation and its association with biologically aggressive phenotype in human breast cancers». Clin. Cancer Res. 11 (4): 1380–5. PMID 15746036. doi:10.1158/1078-0432.CCR-04-1773
- Kuninaka S, Nomura M, Hirota T, et al. (2005). «The tumor suppressor WARTS activates the Omi / HtrA2-dependent pathway of cell death». Oncogene. 24 (34): 5287–98. PMID 16007220. doi:10.1038/sj.onc.1208682
- Bothos J, Tuttle RL, Ottey M, et al. (2005). «Human LATS1 is a mitotic exit network kinase». Cancer Res. 65 (15): 6568–75. PMID 16061636. doi:10.1158/0008-5472.CAN-05-0862
- Jiang Z, Li X, Hu J, et al. (2007). «Promoter hypermethylation-mediated down-regulation of LATS1 and LATS2 in human astrocytoma». Neurosci. Res. 56 (4): 450–8. PMID 17049657. doi:10.1016/j.neures.2006.09.006
Content Disclaimer
Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.
- The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
- There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
- It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
- Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
- Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.