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CASP8AP2
Estruturas disponíveis
PDB	Pesquisa Human UniProt: PDBe RCSB
Lista de códigos id do PDB
	2LR8
Identificadores
Nomes alternativos	CASP8AP2
IDs externos	OMIM: 606880 HomoloGene: 8066 GeneCards: CASP8AP2
Ontologia genética
Função molecular	• peptidase activator activity involved in apoptotic process; • DNA binding; • death receptor binding; • GO:0001106 transcription corepressor activity; • SUMO polymer binding; • GO:0001948, GO:0016582 ligação a proteínas plasmáticas; • cysteine-type endopeptidase activator activity involved in apoptotic process;
Componente celular	• citoplasma; • PML body; • mitocôndria; • núcleo celular; • cariolinfa;
Processo biológico	• GO:0009373 regulation of transcription, DNA-templated; • Fas signaling pathway; • transcription, DNA-templated; • cellular response to mechanical stimulus; • apoptotic signaling pathway; • ciclo celular; • activation of cysteine-type endopeptidase activity involved in apoptotic process; • extrinsic apoptotic signaling pathway via death domain receptors; • GO:0072468 transdução de sinal; • GO:0097285 apoptose; • negative regulation of nucleic acid-templated transcription;
	Sources:Amigo / QuickGO
Ortólogos
	9994
	n/a
	ENSG00000118412; ENSG00000288475
	n/a
	Q9UKL3
	n/a
	NM_012115; NM_001137667; NM_001137668
	n/a
	NP_001131139; NP_001131140; NP_036247
	n/a
	Wikidata
Ver/Editar Humano

A proteína 2 associada a CASP8 é uma proteína que em humanos é codificada pelo gene CASP8AP2.^[2]^[3]^[4]^[5]

Referências

↑ «Human PubMed Reference:»
↑ Imai Y, Kimura T, Murakami A, Yajima N, Sakamaki K, Yonehara S (junho de 1999). «The CED-4-homologous protein FLASH is involved in Fas-mediated activation of caspase-8 during apoptosis». Nature. 398 (6730): 777–85. PMID 10235259. doi:10.1038/19709
↑ Milovic-Holm K, Krieghoff E, Jensen K, Will H, Hofmann TG (janeiro de 2007). «FLASH links the CD95 signaling pathway to the cell nucleus and nuclear bodies». EMBO J. 26 (2): 391–401. PMC 1783462. PMID 17245429. doi:10.1038/sj.emboj.7601504
↑ Barcaroli D, Dinsdale D, Neale MH, Bongiorno-Borbone L, Ranalli M, Munarriz E, Sayan AE, McWilliam JM, Smith TM, Fava E, Knight RA, Melino G, De Laurenzi V (Outubro de 2006). «FLASH is an essential component of Cajal bodies». Proc. Natl. Acad. Sci. U.S.A. 103 (40): 14802–7. PMC 1578500. PMID 17003126. doi:10.1073/pnas.0604225103
↑ «Entrez Gene: CASP8AP2 CASP8 associated protein 2»